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Association of HMOX-1 rs2071747 with sporadic Parkinson’s disease in southern Han Chinese

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Abstract

Study objectives.

To discover the associations between HMOX-1 and sporadic Parkinson’s disease (PD).

Methods

Five hundred sporadic PD patients and 500 healthy controls were recruited in this study. Polymerase chain reaction (PCR) was used.

Results

The dominant model of HMOX-1 rs2071747 was shown statistically significant between PD patients and control after adjustment of age and gender (dominant model: p value: 0.045, OR: 1.51, 95% CI: 1.01–2.27, adjusted). The associations of additive model and dominant model of rs2071747 were also found (additive model: p value: 0.047; dominant model: p value: 0.035, OR: 1.55, 95% CI: 1.03, 2.34).

Conclusions

We found the association of the dominant of HMOX1 rs2071747 with PD. We also found the associations of additive model and dominant model of HMOX1 rs2071747 with late onset PD (LOPD) patients.

Highlights

• The dominant model of HMOX1 rs2071747 was associated with PD.

• The additive model of HMOX1 rs2071747 was associated with LOPD.

• The dominant model of HMOX1 rs2071747 was associated with LOPD.

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Abbreviations

CI:

Confidence interval

EOPD:

Early onset Parkinson’s disease

HO-1:

Heme oxygenase-1

HWE:

Hardy-Weinberg equilibrium

LOPD:

Late onset Parkinson’s disease

MDS:

Movement disorders society

NCBI:

National Center for Biotechnology Information

OR:

Odds ratio

PCR:

Polymerase chain reaction

PD:

Parkinson’s disease

SNP:

Single nucleotide polymorphism

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Acknowledgements

We thank all the patients who participated in this study.

Funding

This work was supported by grants from the National Natural Science Foundation of China 81601106 (to Ran Xiong).

the national natural science foundation of china,81601106,Ran Xiong

Author information

Authors and Affiliations

  1. Department of Neurology, East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Pudong New Area, Shanghai, 200120, China

    Ran Xiong & Bei Zhang

Authors
  1. Ran Xiong
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  2. Bei Zhang
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Contributions

Ran Xiong collected the PD and control data, performed the statistical analysis, and drafted the manuscript. Bei Zhang collected the PD data. Ran Xiong designed the study, supervised the study, double-checked the statistical analysis, and revised the manuscript.

Corresponding author

Correspondence to Ran Xiong.

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Conflict of interest

The authors declare no competing interests.

Ethical approval

This study was approved by the ethic committee of East Hospital, Tongji University School of Medicine. There were no participants whose age was under 18 years old when we assess

Informed consent statement

All participants and their caregivers were fully informed. They signed written consent forms after informed.

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Xiong, R., Zhang, B. Association of HMOX-1 rs2071747 with sporadic Parkinson’s disease in southern Han Chinese. Neurol Sci 43, 3671–3675 (2022). https://doi.org/10.1007/s10072-021-05830-x

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  • DOI: https://doi.org/10.1007/s10072-021-05830-x

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