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Fatigue is related to depression in idiopathic dystonia

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Abstract

Introduction

Dystonia is a movement disorder presented with involuntary muscle contraction causing abnormal posture, movement, or both. Besides motor symptoms, patients may also report non-motor symptoms such as pain, anxiety, apathy, depression, sleep problems, fatigue, and cognitive impairment. The etiology of fatigue in patients with dystonia is not yet well understood.

Aim

To evaluate the presence of fatigue, depression, anxiety, sleep disorders, and daily sleepiness in patients with focal and segmental dystonia and to determine which of these non-motor symptoms influence the occurrence and severity of fatigue.

Patients and methods

Patients were surveyed for symptoms of fatigue, depression, anxiety, night-time sleep problems, and daily sleepiness using the Fatigue Assessment Scale, Beck Depression Inventory II, Beck Anxiety Inventory, Pittsburgh Sleep Questionnaire Index, and Epworth Sleepiness Scale. Demographic data (sex, age, and disease duration) were collected from patient medical records. On statistical analysis, we used SPSS for Windows 10. The level of significance was set at p<0.05.

Results

Sixty patients (43 female and 17 male) with focal or segmental dystonia were evaluated. Fatigue was reported by 67.2% of patients. Fatigue (general, physical, and mental fatigue) was found to correlate with depression, anxiety, and sleep problems. Daily sleepiness correlated only with mental fatigue. Disease duration, age, and gender did not influence the symptoms of fatigue. Multiple regression analysis showed that depression mostly predicted symptoms of general, physical, and mental fatigue.

Conclusion

Depression mostly predicted symptoms of general, physical, and mental fatigue in patients with focal and segmental dystonia.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Neurology, Osijek University Hospital Centre, J. Huttlera 4, Osijek, Croatia

    Svetlana Tomic, Tihana Gilman Kuric, Zvonimir Popovic & Tea Mirosevic Zubonja

  2. Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, J. Huttlera 4, HR-31000, Osijek, Croatia

    Svetlana Tomic, Tihana Gilman Kuric, Zvonimir Popovic & Tea Mirosevic Zubonja

Authors
  1. Svetlana Tomic
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  2. Tihana Gilman Kuric
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  3. Zvonimir Popovic
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  4. Tea Mirosevic Zubonja
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Contributions

All authors contributed to the study conception and design. Conceptualization: Tomic Svetlana; methodology: Tomic Svetlana; formal analysis and investigation: Tomic Svetlana, Gilman Kuric Tihana, Popovic Zvonimir; writing–original draft preparation: Tomic Svetlana; writing–review and editing: Mirosevic Zubonja Tea. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Svetlana Tomic.

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Conflict of interest

Svetlana Tomic received speaking fee from AbbVie d.o.o., Pliva Hrvatska d.o.o., Phoenix Pharmacia d.o.o., Sanofi-Aventis Croatia d.o.o., Novartis Hrvatska d.o.o., Fresenius Kabi d.o.o., Makpharm d.o.o., Medis Adria d.o.o., and Merz Pharmaceuticals GmbH and has received travel support for congress from Medis Adria d.o.o.; Tihana Gilman Kuric received speaking fee from Novartis Hrvatska d.o.o. and has received travel support for congress from Medis Adria d.o.o. and Makpharm d.o.o; Zvonimir Popovic received speaking fee from Novartis Hrvatska d.o.o; Tea Mirosevic Zubonja received speaking fee from Novartis Hrvatska d.o.o, Roche d.o.o., Pliva Hrvatska d.o.o., and Merck d.o.o.

Ethics approval and consent to participate

Approval was obtained from the Ethics committee of Osijek University Hospital Center. The procedures used in this study adhere to the tenets of the Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study.

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Tomic, S., Kuric, T.G., Popovic, Z. et al. Fatigue is related to depression in idiopathic dystonia. Neurol Sci 43, 373–378 (2022). https://doi.org/10.1007/s10072-021-05322-y

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  • DOI: https://doi.org/10.1007/s10072-021-05322-y

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