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Early suspicion of progressive supranuclear palsy using dopamine transporter imaging: an illustrative case presenting with levodopa-responsive parkinsonism

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Funding

This work was supported by the Soonchunhyang University Research Fund (Grant No. 20200432).

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Authors and Affiliations

  1. Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, Republic of Korea

    Hyunjin Ju, Eun Ji Lee, Mina Lee & Kyum-Yil Kwon

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  1. Hyunjin Ju
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  2. Eun Ji Lee
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  3. Mina Lee
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  4. Kyum-Yil Kwon
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Contributions

Conceptualization: Kwon KY; Data curation: Ju H, Lee EJ, Lee M, Kwon KY; Formal analysis: Ju H, Lee EJ, Lee M, Kwon KY; Funding acquisition: Kwon KY; Investigation: Ju H, Lee EJ, Lee M, Kwon KY; Writing - original draft: Ju H, Kwon KY; Writing - review & editing: Ju H, Lee EJ, Lee M, Kwon KY

Corresponding author

Correspondence to Kyum-Yil Kwon.

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The authors declare no competing interests.

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This article does not contain any studies with human participants besides routine clinical diagnostics by any of the authors.

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Written informed consent was obtained from the patient.

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Supplementary Information

Video 1

Initial neurological manifestations of the patient. The patient showed a mild degree of akinetic rigid parkinsonism, which was slightly severe in the right limbs compared with the left limbs. The limitation of the extraocular muscles was not observed, while slowness of her saccadic eye movements including the “Round the Houses” sign was suspiciously noted. Her gait and postural stability were unremarkable (MP4 59579 kb)

Video 2

Clinical presentations of the patient one year after. The patient revealed sustained responsiveness of akinetic rigid parkinsonism of all the limbs with a mild degree of dyskinetic movements. Downward supranuclear gaze palsy and apraxia of eyelid opening were noted. In addition, the patient had postural instability and unsteadiness of tandem gait (MP4 73175 kb)

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Ju, H., Lee, E.J., Lee, M. et al. Early suspicion of progressive supranuclear palsy using dopamine transporter imaging: an illustrative case presenting with levodopa-responsive parkinsonism. Neurol Sci 42, 3435–3437 (2021). https://doi.org/10.1007/s10072-021-05246-7

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  • DOI: https://doi.org/10.1007/s10072-021-05246-7

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