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Psychometric features of Neuropathic Pain Symptom Inventory in Iranian people with Parkinson’s disease

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Abstract

Objective

Neuropathic pain is a type of pain reported in people with Parkinson’s disease. There are various scales to evaluate the characteristics of this kind of pain. The purpose of this study was to investigate the psychometric properties of the Neuropathic Pain Symptom Inventory (NPSI), a specific scale that measures neuropathic pain in Iranian people with Parkinson’s disease.

Method

Four hundred forty-seven individuals with Parkinson’s disease were recruited in the study. Acceptability, internal consistency (Cronbach’s alpha), and test-retest reliability (intraclass correlation coefficient, ICC) of NPSI were calculated. Dimensionality was examined through exploratory factor analysis. For convergent validity, correlations of NPSI with Douleur Neuropathic 4, Brief Pain Inventory, King’s Pain Parkinson disease Scale, and Visual Analog Scale-Pain were used. Discriminative validity and sensitivity to change between On- and Off- medication states were analyzed.

Results

A marked floor effect was observed for this scale (64.2%). Cronbach’s alpha and ICC were 0.90 and 0.87, respectively. Items of NPSI were placed in 4 factors. A moderate to the strong association (rs = 0.55 to 0.85) between NPSI and other scales was obtained. The results of discriminative validity and sensitivity to change indicate the ability of NPSI to show differences between medication states.

Conclusion

The results of this study suggest that NPSI has acceptable reliability, validity, and sensitivity to change, indicating that this scale is suitable for measuring neuropathic pain in Iranian people with Parkinson’s disease.

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Data availability

The data used to support the findings of this study are included within the article.

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Acknowledgments

The authors thank the patients for making this study possible through their participation. The authors are also grateful to Dr. Bouhassira Didier for the kind assistance and insightful comments. The authors are also appreciative of Mr. Taati and Ms. Aghaeipour for the kind support.

Author information

Authors and Affiliations

  1. Rehabilitation Research Center, Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Science, Tehran, Iran

    Ghorban Taghizadeh

  2. National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain

    Carmen Rodriguez-Blazquez

  3. Department of Neurosciences, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Shahid Hemmat Highway, 1449614535, Tehran, Iran

    Mohammad Taghi Joghataei & Maryam Mehdizadeh

  4. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

    Mohammad Taghi Joghataei & Maryam Mehdizadeh

  5. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran

    Sepideh Goudarzi

  6. Department of Neurology, Rasoul Akram Hospital, Iran University of Medical Science, Tehran, Iran

    Sayed Amir Hasan Habibi

  7. Department of Occupational Therapy, School of Rehabilitation Sciences, Semnan University of Medical Science, Semnan, Iran

    Merat Bakhsheshi

  8. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden

    Seyed-Mohammad Fereshtehnejad

  9. Division of Neurology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada

    Seyed-Mohammad Fereshtehnejad

Authors
  1. Ghorban Taghizadeh
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  2. Carmen Rodriguez-Blazquez
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  3. Mohammad Taghi Joghataei
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  4. Sepideh Goudarzi
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  5. Sayed Amir Hasan Habibi
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  6. Merat Bakhsheshi
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  7. Maryam Mehdizadeh
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  8. Seyed-Mohammad Fereshtehnejad
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Corresponding author

Correspondence to Maryam Mehdizadeh.

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The authors claim that there is no conflict of interest.

Ethical approval

The study has been approved by the Student Research Committee of Iran University of Medical Sciences with the ethical code IR.IUMS.rec.1395.95.04-193-30127.

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Taghizadeh, G., Rodriguez-Blazquez, C., Joghataei, M.T. et al. Psychometric features of Neuropathic Pain Symptom Inventory in Iranian people with Parkinson’s disease. Neurol Sci 42, 3233–3239 (2021). https://doi.org/10.1007/s10072-020-04941-1

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  • DOI: https://doi.org/10.1007/s10072-020-04941-1

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