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Can Systemic Immune-Inflammation Index (SII) be a prognostic factor of Bell’s palsy patients?

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Abstract

Objective

Recent studies showed that the neutrophil-to-lymphocyte ratio (NLR) and that platelet-to-lymphocyte ratio (PLR) can be used as inflammatory markers in Bell’s palsy. In this study, the aim is to investigate a novel inflammatory index, the Systemic Immune-Inflammation Index (SII), defined as SII = platelets × neutrophils/lymphocytes, in Bell’s palsy patients.

Study design

Retrospective.

Setting

Clinical research center.

Patients

The study included 88 Bell’s palsy patients and 50 healthy controls.

Interventions

Patients diagnosed with Bell’s palsy from 2010 to 2019 in a university hospital and an age- and sex-matched healthy control group were included in the study retrospectively. A complete blood count was performed for all participants. Magnetic resonance imaging was applied for Bell’s palsy patients for the exclusion of other diagnoses.

Main outcome measures

The CBC parameters were analyzed and hemoglobin, erythrocytes, leukocytes, neutrophils, lymphocytes, and platelet counts were measured. The PLR, NLR, and SII values were calculated with the formula.

Results

The patient group had higher neutrophil counts and higher SII and NLR values than the control group (p < 0.05). Also, SII value is a prognostic factor in Bell’s palsy in our study.

Conclusions

Bell’s palsy has an inflammatory component. The SII value can indicate an inflammatory condition in these patients. It may be used as a marker and prognostic indicator in Bell’s palsy.

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Author information

Authors and Affiliations

  1. Ear Nose and Throat Head and Neck Diseases, Afyonkarahisar State Hospital, Orhangazi Nedim Helvacıoğlu Blv. No:73, Afyonkarahisar, Turkey

    Abdullah Kınar

  2. Department of Ear Nose and Throat Head and Neck Diseases, Afyonkarahisar Health Sciences University School of Medicine, Afyonkarahisar, Turkey

    Şahin Ulu & Abdulkadir Bucak

  3. Department of Internal Medicine, Afyonkarahisar Health Sciences University School of Medicine, Afyonkarahisar, Turkey

    Elif Kazan

Authors
  1. Abdullah Kınar
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  2. Şahin Ulu
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  3. Abdulkadir Bucak
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  4. Elif Kazan
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Corresponding author

Correspondence to Abdullah Kınar.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional (Afyonkarahisar Health Sciences University Ethical Committee) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Kınar, A., Ulu, Ş., Bucak, A. et al. Can Systemic Immune-Inflammation Index (SII) be a prognostic factor of Bell’s palsy patients?. Neurol Sci 42, 3197–3201 (2021). https://doi.org/10.1007/s10072-020-04921-5

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  • DOI: https://doi.org/10.1007/s10072-020-04921-5

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