Abstract
Celiac disease (CD) is an immune-mediated systemic disorder triggered by gluten and related prolamins in genetically predisposed individuals. Here, we described a case of a 31-year-old Caucasian woman who exhibited cerebellar and psychiatric dysfunctions. The patient underwent single-photon emission computed tomography (SPECT-CT) before and after a gluten-free diet (GFD). There was an improvement in cerebellar perfusion accompanied by a remission of cerebellar manifestations. The maintenance of the psychiatric manifestations was related to the persistence of the hypoperfusion in the frontal lobes. The patient’s psychiatric symptoms did not change after 4 months under a GFD in the hospital. To our knowledge, this is the first case that shows the relationship between improvement in cerebellar perfusion and remission of cerebellar clinical manifestations in a CD patient under a GFD.
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Schmidt, J.J., Schmidt, G.J., Tolentino, J.C. et al. A serial SPECT-CT study in a celiac disease patient with cerebellar ataxia and psychiatric symptoms. Neurol Sci 42, 1545–1548 (2021). https://doi.org/10.1007/s10072-020-04908-2
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DOI: https://doi.org/10.1007/s10072-020-04908-2