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Neuropsychiatric symptoms and striatal monoamine availability in early Parkinson’s disease without dementia

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A Correction to this article was published on 10 November 2020

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Abstract

Background and objective

Neuropsychiatric symptoms are relatively common in Parkinson’s disease (PD). Many studies have revealed that striatal monoamine availability is associated with specific neuropsychiatric symptoms. This study was aimed to investigate the association between comprehensive neuropsychiatric symptoms and striatal monoamine availability in patients with early PD without dementia.

Methods

A total of 156 newly diagnosed patients with PD without dementia were included. All patients’ mental and behavioral problems were assessed with the 12-item Neuropsychiatric Inventory (NPI). They underwent positron emission tomography (PET) with 18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane and brain magnetic resonance imaging (MRI). Patients were divided into no neuropsychiatric symptoms and neuropsychiatric symptoms groups according to total NPI score. After normalizing the PET images to spatially normalized MRI, regional standardized uptake value ratios (SUVRs) with a volume of interest template were analyzed for the two groups.

Results

Ninety-eight patients had more than one neuropsychiatric symptom. The SUVR of the thalamus in neuropsychiatric symptoms group was significantly lower than the SUVR in no neuropsychiatric symptoms group independent of age, sex, disease duration, or severity of motor symptoms.

Conclusion

Patients with early PD who have neuropsychiatric symptoms had a lower monoamine availability in the thalamus than those with no neuropsychiatric symptoms. This finding suggests that decreased monoamine transporter availability in the thalamus may be an imaging biomarker of neuropsychiatric symptoms in patients with PD.

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  • 10 November 2020

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Funding

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT (NRF-2017R1D1A1B06028086 and NRF-2019R1G1A1099554), and by the financial support of the Catholic Medical Center Research Foundation made in the program year of 2019. The funder had no role in study design, data collection and analysis, the decision to publish or manuscript preparation.

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Authors and Affiliations

  1. Department of Neurology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, 06591, Seoul, Republic of Korea

    Yoon-Sang Oh, Jean Hee Kim, Sang-Won Yoo, Kwang-Soo Lee & Joong-Seok Kim

  2. Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

    Eo-Jin Hwang

  3. Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Chul Hyoung Lyoo

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Correspondence to Joong-Seok Kim.

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Seoul St. Mary’s Hospital ethics committee approved the study and all participants signed informed consent.

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Oh, YS., Kim, J.H., Yoo, SW. et al. Neuropsychiatric symptoms and striatal monoamine availability in early Parkinson’s disease without dementia. Neurol Sci 42, 711–718 (2021). https://doi.org/10.1007/s10072-020-04859-8

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