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Correlation analysis between serum procalcitonin and infarct volume in young patients with acute cerebral infarction

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Abstract

Objective

To detect the serum procalcitonin (PCT) level and determine its relationship with the infarct volume in young patients with acute cerebral infarction.

Methods

According to the infarct volume, young patients with acute cerebral infarction were divided into large group, intermediate group, and small group. The severity of clinical symptoms was determined according to the National Institute of Health Stroke Scale (NIHSS) score. Healthy young people were selected as the control group. Serum PCT levels were measured. The relationship among PCT, volume, and NIHSS score was analyzed.

Results

PCT in observation group was significantly higher than that in control group (t = 6.879, P = 0.011), and PCT in severe group was significantly higher than in mild group (t = 6.978, P = 0.016). PCT in large cerebral infarction group was higher than that in intermediate and small-size infarct group (P = 0.0036 and P < 0.0001, respectively), and PCT in intermediate cerebral infarction group was higher than that in small-size infarct group (P = 0.0024). In observation group, the PCT level was positively correlated with both NIHSS (r = 0.793, P = 0.022) and infarction volume (r = 0.649, P = 0.007).

Conclusion

The level of PCT in young patients with acute cerebral infarction may be related to the inflammatory reaction of the cerebral artery and positively related to the volume of cerebral infarction and NIHSS score. To some extent, PCT concentration can predict the disease severity of acute cerebral infarction.

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Data availability

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Abbreviations

PCT:

Procalcitonin

NIHSS:

National Institute of Health Stroke Scale

DWI:

Diffusion-weighted imaging

BMI:

Body mass index

ELISA:

Enzyme-linked immunosorbent assay

EDTA:

Ethylenediaminetetraacetic acid

AIS:

Acute ischemic stroke

LCI:

Large cerebral infarction

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Authors and Affiliations

  1. Department of Neurology, Baoji Municipal Central Hospital, 8 Jiangtan Road, Baoji, 721008, Shaanxi, People’s Republic of China

    Huijun Wen & Maikou Lv

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  1. Huijun Wen
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  2. Maikou Lv
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Contributions

Huijun Wen designed and implemented the experiment, collected and processed the data, and wrote the first draft of the thesis, and Maikou Lv improved the experiment and revised the thesis.

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Correspondence to Maikou Lv.

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Ethical statement

This study was performed in line with the principles of the Declaration of Helsinki. The research protocol was approved by the Ethical Committee of the Baoji Municipal Central Hospital, China.

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Informed consent was obtained from all individual participants included in the study.

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Informed consent has been obtained from the patient to use the information in this paper for publication.

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Wen, H., Lv, M. Correlation analysis between serum procalcitonin and infarct volume in young patients with acute cerebral infarction. Neurol Sci 42, 3189–3196 (2021). https://doi.org/10.1007/s10072-020-04856-x

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