Skip to main content

Advertisement

SpringerLink
Log in

Prediction of mTICI 3 recanalization and clinical outcomes in endovascular thrombectomy for acute ischemic stroke: a retrospective study in the Taiwan registry

  • Original Article
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Purpose

Early recanalization for acute ischemic stroke (AIS) due to large vessel occlusion (LVO) by endovascular thrombectomy (EVT) is strongly related to improved functional outcomes. With data obtained from the Taiwan registry, the factors associated with mTICI 3 recanalization and clinical outcomes in EVT are investigated.

Methods

From January 2014 to September 2016, 108 patients who underwent EVT for AIS due to LVO in 11 medical centers throughout Taiwan were included. Complete recanalization is defined as achieving modified thrombolysis in cerebral infarction (mTICI) grade 3. Good clinical outcomes are defined by the modified Rankin scale (mRS) 0–2 at 3 months after EVT. Clinical and imaging parameters for predicting mTICI 3 recanalization and good clinical outcomes are analyzed.

Results

Of the 108 patients who received EVT, 54 (50%) patients had mTICI 3 recanalization. Having received aspiration only and the use of IV-tPA are shown to be significant predictors for mTICI 3 recanalization with odds ratios of 2.61 and 2.53 respectively. Forty-six (42.6%) patients experienced good 3-month clinical outcomes (mRS 0–2). Pretreatment collateral statuses, NIHSS scores, time lapses between symptoms to needle, and the occurrence of hemorrhage at 24 h are all significant predictors for good outcomes with odds ratios of 2.88, 0.91, 0.99, and 0.31 respectively.

Conclusions

Prediction of mTICI 3 recanalization and clinical outcomes offer valuable clinical information for treatment planning in EVT.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Smith WS, Tsao JW, Billings ME, Johnston SC, Hemphill JC 3rd, Bonovich DC, Dillon WP (2006) Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia. Neurocrit Care 4(1):14–17

    Article  Google Scholar 

  2. Disorders NIoN, Group Sr-PSS (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333(24):1581–1588

    Article  Google Scholar 

  3. Rha J-H, Saver JL (2007) The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 38(3):967–973

    Article  Google Scholar 

  4. Saqqur M, Uchino K, Demchuk AM, Molina CA, Garami Z, Calleja S, Akhtar N, Orouk FO, Salam A, Shuaib A (2007) Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke 38(3):948–954

    Article  Google Scholar 

  5. Kim YS, Garami Z, Mikulik R, Molina CA, Alexandrov AV (2005) Early recanalization rates and clinical outcomes in patients with tandem internal carotid artery/middle cerebral artery occlusion and isolated middle cerebral artery occlusion. Stroke 36(4):869–871

    Article  Google Scholar 

  6. Flottmann F, Leischner H, Broocks G, Nawabi J, Bernhardt M, Faizy TD, Deb-Chatterji M, Thomalla G, Fiehler J, Brekenfeld C (2018) Recanalization rate per retrieval attempt in mechanical thrombectomy for acute ischemic stroke. Stroke 49(10):2523–2525

    Article  Google Scholar 

  7. Jayaraman M, Grossberg J, Meisel K, Shaikhouni A, Silver B (2013) The clinical and radiographic importance of distinguishing partial from near-complete reperfusion following intra-arterial stroke therapy. Am J Neuroradiol 34(1):135–139

    Article  CAS  Google Scholar 

  8. Kleine JF, Wunderlich S, Zimmer C, Kaesmacher J (2017) Time to redefine success? TICI 3 versus TICI 2b recanalization in middle cerebral artery occlusion treated with thrombectomy. J Neurointerv Surg 9(2):117–121. https://doi.org/10.1136/neurintsurg-2015-012218

    Article  PubMed  Google Scholar 

  9. Tung EL, McTaggart RA, Baird GL, Yaghi S, Hemendinger M, Dibiasio EL, Hidlay DT, Tung GA, Jayaraman MV (2017) Rethinking thrombolysis in cerebral infarction 2b: which thrombolysis in cerebral infarction scales best define near complete recanalization in the modern thrombectomy era? Stroke 48(9):2488–2493

    Article  Google Scholar 

  10. Carvalho A, Santos T, Cunha A, Gregório T, Paredes L, Costa H, Castro S, Ribeiro M, Veloso M, Barros P (2018) Need for refining successful revascularization in endovascular treatment of acute ischemic stroke: data from real-world. J Neurol Sci 384:129–132

    Article  Google Scholar 

  11. Dargazanli C, Fahed R, Blanc R, Gory B, Labreuche J, Duhamel A, Marnat G, Saleme S, Costalat V, Bracard S, Desal H, Mazighi M, Consoli A, Piotin M, Lapergue B (2018) Modified thrombolysis in cerebral infarction 2c/thrombolysis in cerebral infarction 3 reperfusion should be the aim of mechanical thrombectomy: insights from the ASTER Trial (Contact Aspiration Versus Stent Retriever for Successful Revascularization). Stroke 49(5):1189–1196. https://doi.org/10.1161/strokeaha.118.020700

    Article  PubMed  Google Scholar 

  12. Kaesmacher J, Dobrocky T, Heldner MR, Bellwald S, Mosimann PJ, Mordasini P, Bigi S, Arnold M, Gralla J, Fischer U (2018) Systematic review and meta-analysis on outcome differences among patients with TICI2b versus TICI3 reperfusions: success revisited. J Neurol Neurosurg Psychiatry 89(9):910–917. https://doi.org/10.1136/jnnp-2017-317602

    Article  PubMed  PubMed Central  Google Scholar 

  13. Yoon W, Kim SK, Park MS, Baek BH, Lee YY (2017) Predictive factors for good outcome and mortality after stent-retriever thrombectomy in patients with acute anterior circulation stroke. J Stroke 19(1):97–103. https://doi.org/10.5853/jos.2016.00675

    Article  PubMed  PubMed Central  Google Scholar 

  14. Ozdemir O, Giray S, Arlier Z, Baş DF, Inanc Y, Colak E (2015) Predictors of a good outcome after endovascular stroke treatment with stent retrievers. Sci World J 2015:403726. https://doi.org/10.1155/2015/403726

  15. Costalat V, Lobotesis K, Machi P, Mourand I, Maldonado I, Heroum C, Vendrell J, Milhaud D, Riquelme C, Bonafé A (2012) Prognostic factors related to clinical outcome following thrombectomy in ischemic stroke (RECOST study). 50 patients prospective study. Eur J Radiol 81(12):4075–4082

    Article  CAS  Google Scholar 

  16. Soize S, Barbe C, Kadziolka K, Estrade L, Serre I, Pierot L (2013) Predictive factors of outcome and hemorrhage after acute ischemic stroke treated by mechanical thrombectomy with a stent-retriever. Neuroradiology 55(8):977–987

    Article  Google Scholar 

  17. McVerry F, Liebeskind DS, Muir KW (2012) Systematic review of methods for assessing leptomeningeal collateral flow. AJNR Am J Neuroradiol 33(3):576–582. https://doi.org/10.3174/ajnr.A2794

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Souza LC, Yoo AJ, Chaudhry ZA, Payabvash S, Kemmling A, Schaefer PW, Hirsch JA, Furie KL, Gonzalez RG, Nogueira RG, Lev MH (2012) Malignant CTA collateral profile is highly specific for large admission DWI infarct core and poor outcome in acute stroke. AJNR Am J Neuroradiol 33(7):1331–1336. https://doi.org/10.3174/ajnr.A2985

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Nambiar V, Sohn SI, Almekhlafi MA, Chang HW, Mishra S, Qazi E, Eesa M, Demchuk AM, Goyal M, Hill MD, Menon BK (2014) CTA collateral status and response to recanalization in patients with acute ischemic stroke. AJNR Am J Neuroradiol 35(5):884–890. https://doi.org/10.3174/ajnr.A3817

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Zaidat OO, Yoo AJ, Khatri P, Tomsick TA, von Kummer R, Saver JL, Marks MP, Prabhakaran S, Kallmes DF, Fitzsimmons BF, Mocco J, Wardlaw JM, Barnwell SL, Jovin TG, Linfante I, Siddiqui AH, Alexander MJ, Hirsch JA, Wintermark M, Albers G, Woo HH, Heck DV, Lev M, Aviv R, Hacke W, Warach S, Broderick J, Derdeyn CP, Furlan A, Nogueira RG, Yavagal DR, Goyal M, Demchuk AM, Bendszus M, Liebeskind DS (2013) Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement. Stroke 44(9):2650–2663. https://doi.org/10.1161/strokeaha.113.001972

    Article  PubMed  PubMed Central  Google Scholar 

  21. Pexman JH, Barber PA, Hill MD, Sevick RJ, Demchuk AM, Hudon ME, Hu WY, Buchan AM (2001) Use of the Alberta Stroke Program Early CT Score (ASPECTS) for assessing CT scans in patients with acute stroke. AJNR Am J Neuroradiol 22(8):1534–1542

    CAS  PubMed  Google Scholar 

  22. Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors J, Demaerschalk BM, Khatri P, McMullan PW Jr, Qureshi AI, Rosenfield K (2013) Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 44(3):870–947

    Article  Google Scholar 

  23. Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S (1999) Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase thrombolysis for acute noninterventional therapy in ischemic stroke. JAMA 282(21):2019–2026. https://doi.org/10.1001/jama.282.21.2019

    Article  CAS  PubMed  Google Scholar 

  24. Martini M, Mocco J, Turk A, Siddiqui AH, Fiorella D, Hanel RA, Woodward K, Rai A, Frei D, Delgado Almandoz JE, Kelly ME, Peeling L, Arthur AS, Baxter B, English J, Linfante I, De Leacy R (2019) 'Real-world' comparison of first-line direct aspiration and stent retriever mechanical thrombectomy for the treatment of acute ischemic stroke in the anterior circulation: a multicenter international retrospective study. J Neurointerv Surg 11(10):957–963. https://doi.org/10.1136/neurintsurg-2018-014624

    Article  PubMed  Google Scholar 

  25. Yoon W, Jung MY, Jung SH, Park MS, Kim JT, Kang HK (2013) Subarachnoid hemorrhage in a multimodal approach heavily weighted toward mechanical thrombectomy with solitaire stent in acute stroke. Stroke 44(2):414–419. https://doi.org/10.1161/strokeaha.112.675546

    Article  PubMed  Google Scholar 

  26. Kim SK, Yoon W, Moon SM, Park MS, Jeong GW, Kang HK (2015) Outcomes of manual aspiration thrombectomy for acute ischemic stroke refractory to stent-based thrombectomy. J Neurointerv Surg 7(7):473–477. https://doi.org/10.1136/neurintsurg-2014-011203

    Article  PubMed  Google Scholar 

  27. van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J (1988) Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19(5):604–607

    Article  Google Scholar 

  28. Qin C, Shang K, Xu SB, Wang W, Zhang Q, Tian DS (2018) Efficacy and safety of direct aspiration versus stent-retriever for recanalization in acute cerebral infarction: a PRISMA-compliant systematic review and meta-analysis. Medicine 97(41):e12770. https://doi.org/10.1097/md.0000000000012770

    Article  PubMed  PubMed Central  Google Scholar 

  29. Phan K, Maingard J, Kok HK, Dmytriw AA, Goyal S, Chandra R, Brooks DM, Thijs V, Asadi H (2018) Contact aspiration versus stent-retriever thrombectomy for distal middle cerebral artery occlusions in acute ischemic stroke: meta-analysis. Neurointervention 13(2):100–109. https://doi.org/10.5469/neuroint.2018.00997

    Article  PubMed  PubMed Central  Google Scholar 

  30. Stapleton CJ, Leslie-Mazwi TM, Torok CM, Hakimelahi R, Hirsch JA, Yoo AJ, Rabinov JD, Patel AB (2018) A direct aspiration first-pass technique vs stentriever thrombectomy in emergent large vessel intracranial occlusions. J Neurosurg 128(2):567–574. https://doi.org/10.3171/2016.11.Jns161563

    Article  PubMed  Google Scholar 

  31. Rai AT, Boo S, Buseman C, Adcock AK, Tarabishy AR, Miller MM, Roberts TD, Domico JR, Carpenter JS (2018) Intravenous thrombolysis before endovascular therapy for large vessel strokes can lead to significantly higher hospital costs without improving outcomes. J Neurointerv Surg 10(1):17–21. https://doi.org/10.1136/neurintsurg-2016-012830

    Article  PubMed  Google Scholar 

  32. Guedin P, Larcher A, Decroix JP, Labreuche J, Dreyfus JF, Evrard S, Wang A, Graveleau P, Tassan P, Pico F, Coskun O, Rodesch G, Bourdain F, Lapergue B (2015) Prior IV thrombolysis facilitates mechanical thrombectomy in acute ischemic stroke. J Stroke Cerebrovasc Dis 24(5):952–957. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.12.015

    Article  PubMed  Google Scholar 

  33. Behme D, Kabbasch C, Kowoll A, Dorn F, Liebig T, Weber W, Mpotsaris A (2016) Intravenous thrombolysis facilitates successful recanalization with stent-retriever mechanical thrombectomy in middle cerebral artery occlusions. J Stroke Cerebrovasc Dis 25(4):954–959. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.007

    Article  PubMed  Google Scholar 

  34. Abilleira S, Ribera A, Cardona P, Rubiera M, Lopez-Cancio E, Amaro S, Rodriguez-Campello A, Camps-Renom P, Canovas D, de Miquel MA, Tomasello A, Remollo S, Lopez-Rueda A, Vivas E, Perendreu J, Gallofre M (2017) Outcomes after direct thrombectomy or combined intravenous and endovascular treatment are not different. Stroke 48(2):375–378. https://doi.org/10.1161/strokeaha.116.015857

    Article  PubMed  Google Scholar 

  35. Angermaier A, Michel P, Khaw AV, Kirsch M, Kessler C, Langner S (2016) Intravenous thrombolysis and passes of thrombectomy as predictors for endovascular revascularization in ischemic stroke. J Stroke Cerebrovasc Dis 25(10):2488–2495. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.06.024

    Article  PubMed  Google Scholar 

  36. Pfefferkorn T, Holtmannspotter M, Patzig M, Bruckmann H, Ottomeyer C, Opherk C, Dichgans M, Fesl G (2012) Preceding intravenous thrombolysis facilitates endovascular mechanical recanalization in large intracranial artery occlusion. Int J Stroke 7(1):14–18. https://doi.org/10.1111/j.1747-4949.2011.00639.x

    Article  PubMed  Google Scholar 

  37. Coutinho JM, Liebeskind DS, Slater LA, Nogueira RG, Clark W, Davalos A, Bonafe A, Jahan R, Fischer U, Gralla J, Saver JL, Pereira VM (2017) Combined intravenous thrombolysis and thrombectomy vs thrombectomy alone for acute ischemic stroke: a pooled analysis of the SWIFT and STAR studies. JAMA Neurol 74(3):268–274. https://doi.org/10.1001/jamaneurol.2016.5374

    Article  PubMed  Google Scholar 

  38. Mulder MJ, Berkhemer OA, Fransen PS, Beumer D, van den Berg LA, Lingsma HF, Roos YB, van Oostenbrugge RJ, van Zwam WH, Majoie CB, van der Lugt A, Dippel DW (2016) Treatment in patients who are not eligible for intravenous alteplase: MR CLEAN subgroup analysis. Int J Stroke 11(6):637–645. https://doi.org/10.1177/1747493016641969

    Article  PubMed  Google Scholar 

  39. Minnerup J, Wersching H, Teuber A, Wellmann J, Eyding J, Weber R, Reimann G, Weber W, Krause LU, Kurth T, Berger K (2016) Outcome after thrombectomy and intravenous thrombolysis in patients with acute ischemic stroke: a prospective observational study. Stroke 47(6):1584–1592. https://doi.org/10.1161/strokeaha.116.012619

    Article  CAS  PubMed  Google Scholar 

  40. Boeckh-Behrens T, Kleine JF, Zimmer C, Neff F, Scheipl F, Pelisek J, Schirmer L, Nguyen K, Karatas D, Poppert H (2016) Thrombus histology suggests cardioembolic cause in cryptogenic stroke. Stroke 47(7):1864–1871. https://doi.org/10.1161/strokeaha.116.013105

    Article  CAS  PubMed  Google Scholar 

  41. Gunning GM, McArdle K, Mirza M, Duffy S, Gilvarry M, Brouwer PA (2018) Clot friction variation with fibrin content; implications for resistance to thrombectomy. J Neurointerv Surg 10(1):34–38. https://doi.org/10.1136/neurintsurg-2016-012721

    Article  PubMed  Google Scholar 

  42. Hashimoto T, Hayakawa M, Funatsu N, Yamagami H, Satow T, Takahashi JC, Nagatsuka K, Ishibashi-Ueda H, Kira JI, Toyoda K (2016) Histopathologic analysis of retrieved thrombi associated with successful reperfusion after acute stroke thrombectomy. Stroke 47(12):3035–3037. https://doi.org/10.1161/strokeaha.116.015228

    Article  CAS  PubMed  Google Scholar 

  43. Ryu CW, Kim BM, Kim HG, Heo JH, Nam HS, Kim DJ, Kim YD (2019) Optimizing outcome prediction scores in patients undergoing endovascular thrombectomy for large vessel occlusions using collateral grade on computed tomography angiography. Neurosurgery 85(3):350–358. https://doi.org/10.1093/neuros/nyy316

    Article  PubMed  Google Scholar 

  44. Seners P, Roca P, Legrand L, Turc G, Cottier JP, Cho TH, Arquizan C, Bracard S, Ozsancak C, Ben Hassen W, Naggara O, Lion S, Debiais S, Berthezene Y, Costalat V, Richard S, Magni C, Mas JL, Baron JC, Oppenheim C (2019) Better collaterals are independently associated with post-thrombolysis recanalization before thrombectomy. Stroke 50(4):867–872. https://doi.org/10.1161/strokeaha.118.022815

    Article  PubMed  Google Scholar 

  45. Broocks G, Kniep H, Schramm P, Hanning U, Flottmann F, Faizy T, Schonfeld M, Meyer L, Schon G, Aulmann L, Machner B, Royl G, Fiehler J, Kemmling A (2019) Patients with low Alberta Stroke Program Early CT Score (ASPECTS) but good collaterals benefit from endovascular recanalization. J Neurointerv Surg. https://doi.org/10.1136/neurintsurg-2019-015308

  46. Jiang S, Fei A, Peng Y, Zhang J, Lu YR, Wang HR, Chen M, Pan S (2015) Predictors of outcome and hemorrhage in patients undergoing endovascular therapy with solitaire stent for acute ischemic stroke. PLoS One 10(12):e0144452. https://doi.org/10.1371/journal.pone.0144452

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Aoki J, Suzuki K, Kanamaru T, Kutsuna A, Katano T, Takayama Y, Nishi Y, Takeshi Y, Nakagami T, Numao S, Abe A, Suda S, Nishiyama Y, Kimura K (2019) Association between initial NIHSS score and recanalization rate after endovascular thrombectomy. J Neurol Sci 403:127–132. https://doi.org/10.1016/j.jns.2019.06.033

    Article  PubMed  Google Scholar 

  48. Shi ZS, Liebeskind DS, Xiang B, Ge SG, Feng L, Albers GW, Budzik R, Devlin T, Gupta R, Jansen O, Jovin TG, Killer-Oberpfalzer M, Lutsep HL, Macho J, Nogueira RG, Rymer M, Smith WS, Wahlgren N, Duckwiler GR (2014) Predictors of functional dependence despite successful revascularization in large-vessel occlusion strokes. Stroke 45(7):1977–1984. https://doi.org/10.1161/strokeaha.114.005603

    Article  PubMed  PubMed Central  Google Scholar 

  49. Mazighi M, Chaudhry SA, Ribo M, Khatri P, Skoloudik D, Mokin M, Labreuche J, Meseguer E, Yeatts SD, Siddiqui AH, Broderick J, Molina CA, Qureshi AI, Amarenco P (2013) Impact of onset-to-reperfusion time on stroke mortality: a collaborative pooled analysis. Circulation 127(19):1980–1985. https://doi.org/10.1161/circulationaha.112.000311

    Article  PubMed  Google Scholar 

  50. Nogueira RG, Gupta R, Jovin TG, Levy EI, Liebeskind DS, Zaidat OO, Rai A, Hirsch JA, Hsu DP, Rymer MM, Tayal AH, Lin R, Natarajan SK, Nanda A, Tian M, Hao Q, Kalia JS, Chen M, Abou-Chebl A, Nguyen TN, Yoo AJ (2015) Predictors and clinical relevance of hemorrhagic transformation after endovascular therapy for anterior circulation large vessel occlusion strokes: a multicenter retrospective analysis of 1122 patients. J Neurointerv Surg 7(1):16–21. https://doi.org/10.1136/neurintsurg-2013-010743

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors wish to thank Hao-Hui Huang, Chi-Jen Chen, Gow-Wei Lee, Shih-Wei Hsu, Pao-Sheng Yen, Yen-Jun Lai, Sho-Jen Cheng, Yu-Hone Hsu, Chang-Hsien Ou, and Ming-Chi Wu for their assistance in the collection of data. The authors wish to thank Jeon-Hor Chen and Ginger Shu for their assistance in critical revision.

Author information

Authors and Affiliations

  1. Department of Medical Imaging, Chi Mei Medical Center, No.901, Zhonghua Rd., Yongkang District, Tainan City, 71004, Taiwan, Republic of China

    Ching-Chung Ko, Tai-Yuan Chen, Te-Chang Wu & Yu-Kun Tsui

  2. Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan, Taiwan

    Ching-Chung Ko

  3. Department of Medical Imaging, Fu Jen Catholic University Hospital, Fu Jen Catholic University, No.69, Guizi Rd., Taishan Dist, New Taipei City, 24352, Taiwan, Republic of China

    Hon-Man Liu

  4. Department of Medical Imaging, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei City, Taiwan

    Hon-Man Liu

  5. Graduate Institute of Medical Sciences, Chang Jung Christian University, Tainan, Taiwan

    Tai-Yuan Chen & Te-Chang Wu

  6. Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

    Te-Chang Wu

  7. Stroke Center and Department of Neurology, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei City, 100, Taiwan, Republic of China

    Li-Kai Tsai, Sung-Chun Tang & Jiann-Shing Jeng

Authors
  1. Ching-Chung Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hon-Man Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tai-Yuan Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Te-Chang Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li-Kai Tsai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sung-Chun Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yu-Kun Tsui
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jiann-Shing Jeng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yu-Kun Tsui.

Ethics declarations

Conflict of interest

None.

Ethical approval

This retrospective study was approved by our Institutional Review Board (IRB serial No. 201507066RIND). Written consent was waived, as this retrospective study does not influence the health care of included individuals. All patients’ data were anonymized and de-identified prior to analysis.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ko, CC., Liu, HM., Chen, TY. et al. Prediction of mTICI 3 recanalization and clinical outcomes in endovascular thrombectomy for acute ischemic stroke: a retrospective study in the Taiwan registry. Neurol Sci 42, 2325–2335 (2021). https://doi.org/10.1007/s10072-020-04800-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-020-04800-z

Keywords

Search

Navigation