Skip to main content

Holmes tremor and palatal tremor in hypertrophic olivary degeneration: involvement of brainstem

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2


  1. Choh NA, Choh SA, Jehangir M (2009) Hypertrophic olivary degeneration: the forgotten triangle of Guillain and Mollaret. Neurol India 57(4):507–509

    Article  Google Scholar 

  2. Vyas S, Prabhakar A, Kumar A, Khandelwal N (2013) Bilateral hypertrophic olivary degeneration. Ann Indian Acad Neurol 16(3):404–405

    Article  Google Scholar 

  3. Dongan SN (2020) Hypertrophic olivary degeneration and Holmes’ tremor: case report and review of the literature. World Neurosurg 137:286–290

    Article  Google Scholar 

  4. Konno T, Broderick DF, Tacik P, Caviness JN, Wszolek ZK (2016) Hypertrophic olivary degeneration: a clinico-radiologic study. Parkinsonism Relat Disord 28:36–40

    Article  Google Scholar 

  5. Raina GB, Cersosimo MG, Folgar SS, Giugni JC, Calandra C, Paviolo JP, Tkachuk VA, Ramirez CZ, Tschopp AL, Calvo DS (2016) Holmes tremor: clinical description, lesion localization, and treatment in a series of 29 cases. Neurology 86(10):931–938

    Article  Google Scholar 

  6. Alexandre A, Botto A, Izzo G, Tartaglione T, Sciandra M, Gaudino S, Colosimo C (2014) Hypertrophic olivary degeneration after cerebellar or brain stem injuries: MRI findings and differential diagnosis. Eur Congress Radiol 2014.

  7. Walker M, Kim H, Samii A (2007) Holmes-like tremor of the lower extremity following brainstem hemorrhage. Mov Disord 22(2):272–274

    Article  Google Scholar 

  8. Mené Ndez DFS, Cury RG, Barbosa ER, Teixeira MJ, Fonoff ET (2014) Hypertrophic olivary degeneration and Holmes’ tremor secondary to bleeding of cavernous malformation in the midbrain. Tremor Other Hyperkinet Mov 4:264

    Article  Google Scholar 

  9. Lee S, Choi J, Son B (2015) Rubral tremors associated with an inferior olivary lesion that developed after a brainstem hemorrhage. Nerve 1(1):50–52

    Article  Google Scholar 

Download references


The authors thank Xian Liu, PhD (Guangdong Hospital of Traditional Chinese Medicine, Department of Radiology) for his specialized guidance.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Lechang Zhan.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflict of interest.

Statistical analysis

No statistical analysis.

Ethical approval

Not applicable

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material


HT is not limited to the upper limbs and could be present in the trunk, especially the pelvis. HT is classically characterized as a combination of rest, postural and kinetic tremors of irregular and coarse amplitudes. (MPG 5348 kb)


Holmes tremor in upper limbs. In this video, we first show tremor enhancement upon the patient raising both upper limbs. Second, we show the right thumb tremor in the resting state. Last, the patient was asked to perform the finger-nose test and could not finish the test; tremor exacerbation occurred when he tried to finish the test. (MPG 8012 kb)


PT with rhythmic palatal contractions, laryngeal muscle spasm and slurred speech. (MPG 6946 kb)

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, X., Zhan, L., Ling, S. et al. Holmes tremor and palatal tremor in hypertrophic olivary degeneration: involvement of brainstem. Neurol Sci 42, 1157–1159 (2021).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: