Behçet’s disease (BD) is a multisystemic perivasculitis with recurrent oral aphthous ulcers, genital ulcers, and eye involvement which was first described in 1937. Neurological involvement in BD patients is referred to as neuro-Behçet’s disease (NBD). Studies have shown that BD worsens quality of life. However, there is no study that conducts a head-to-head comparison of quality of life between NBD patients and healthy controls.
Forty patients with NBD and 39 age-sex-matched healthy control subjects were included in this study. Sociodemographic data of all participants were recorded; SF-36 was used to assess quality of life.
NBD patients had significantly lower SF-36 scores of physical functioning, physical difficulty, bodily pain, and general health perception compared with healthy controls. However, there was no significant difference between the groups according to the SF-36 scores of role limitation due to emotional problems, mental health, vitality, and social functioning. There was no significant difference between parenchymal and non-parenchymal NBD groups according to SF-36, Beck’s Depression Inventory, and Beck’s Anxiety Inventory scores. Patients with cerebellar system involvement had significantly lower physical and social functioning scores compared with those who did not. Patients with brain stem involvement were found to have higher role limitation due to emotional problems, vitality, social functioning, physical pain, and general health perception scores compared with those without brain stem findings.
NBD negatively affects many aspects of the quality of life.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
All data generated or analyzed during this study are included in this published article (and its supplementary information files).
Sakane T, Takeno M, Suzuki N, Inaba G (1999) Behcet’s disease. N Engl J Med 341(17):1284–1291
Verity DH, Marr JE, Ohno S, Wallace GR, Stanford MR (1999) Behcet’s disease, the Silk Road and HLA-B51: historical and geographical perspectives. Tissue Antigens 54(3):213–220
Yazici H, Tuzun Y, Pazarli H, Yurdakul S, Ozyazgan Y, Ozdogan H, Serdaroglu S, Ersanli M, Ulku BY, Muftuoglu AU (1984) Influence of age of onset and patient’s sex on the prevalence and severity of manifestations of Behcet’s syndrome. Ann Rheum Dis 43(6):783–789
Kalra S, Silman A, Akman-Demir G, Bohlega S, Borhani-Ha A, Constantinescu CS, Houman H, Mahr A, Salvarani C, Sfikakis PP, Siva A, Al-Araji A (2014) Diagnosis and management of neuro-Behcet’s disease: international consensus recommendations. J Neurol 261(9):1662–1676
Aykac SC, Gökcay F, Calli C (2019) What is the role of diffusion tensor imaging (DTI) in detecting subclinical pyramidal tract dysfunction in Behçet’s and neuro-Behçet’s cases? Neurological Sciences 40(4):753–758
Al-Araji A, Kidd DP (2009) Neuro-Behcet’s disease: epidemiology, clinical characteristics, and management. Lancet Neuro 18(2):192–204
Uygunoğlu U, Siva A (2018) Behçet’s syndrome and nervous system involvement. Current neurology and neuroscience reports 18(7):35
Davatchi F, Chams-Davatchi C, Shams H, Shahram F, Nadji A, Akhlai M, Faezi T, Odsi Z, ABHollahi BS, Ashofteh F, Mohtasham N, Kavosi H, Masoumi M (2017) Behcet’s disease: epidemiology, clinical manifestations, and diagnosis. Expert Rev Clin Immunol 13(1):57–65
Kidd D, Steuer A, Denman AM, Rudge P (1999) Neurological complications in Behcet’s syndrome. Brain 122(Pt 11):2183–2194
Akman-Demir G, Serdaroglu P, Tasci B (1999) Clinical patterns of neurological involvement in Behcet’s disease: evaluation of 200 patients. The Neuro-Behcet Study Group. Brain 122(Pt 11):2171–2182
Siva A, Kantarci OH, Saip S, Altintas A, Hamuryudan V, Islak C, Kocer N, Yazici H (2001) Behcet’s disease: diagnostic and prognostic aspects of neurological involvement. J Neurol 248(2):95–103 (2006)
Bodur H, Borman P, Ozdemir Y, Atan C, Kural G (2006) Quality of life and life satisfaction in patients with Behcet’s disease: relationship with disease activity. Clin Rheumatol 25(3):329–333
Bernabe E, Marcenes W, Mather J, Phillips C, Fortune F (2010) Impact of Behcet’s syndrome on health-related quality of life: influence of the type and number of symptoms. Rheumatology (Oxford) 49(11):2165–2171
Canpolat O, Yurtsever S (2011) The quality of life in patients with Behcet’s disease. Asian Nurs Res (Korean Soc Nurs Sci) 5(4):229–235
(1990) Criteria for diagnosis of Behcet’s disease. International Study Group for Behcet’s Disease. Lancet 335(8697):1078–1080
Vladetić M, Jančuljak D, Soldo SB, Kralik K, Buljan K (2017) Health-related quality of life and ways of coping with stress in patients with migraine. Neurol Sci 38(2):295–301
Hamuryudan V, Fresko I, Direskeneli H, Tenant MJ, Yurdakul S, Akoglu T, Yazici H (1999 Aug) Evaluation of the Turkish translation of a disease activity form for Behçet's syndrome. Rheumatology (Oxford). 38(8):734–736
Koçyiğit HA, Ö, Ölmez N, Memiş A (1999) SF-36’ nın Türkçe için güvenilirliği ve geçerliliği. İlaç ve Tedavi Dergisi 12:102–106
Fabiani C, Vitale A, Orlando I, Sota J, Capozzoli M, Franceschini R, Galeazzi M, Tosi GM, Frediani B, Cantarini L (2017) Quality of life impairment in Behcet’s disease and relationship with disease activity: a prospective study. Emerg Med Intern. 12(7):947–955
The research was supported by ourselves.
Conflict of interest
The authors declare that they have no conflicts of interest.
The study conforms to the principles outlined in the Declaration of Helsinki. Ankara University School of Medicine clinical research ethics committee has approved the study protocols at July 27, 2015 (registrations number: 12.507.05).
Consent to participate
Consent for publication
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
About this article
Cite this article
Kuzu Kumcu, M., Bakırarar, B. & Yücesan, C. Quality of life in neuro-Behçet’s disease: a cross-sectional study. Neurol Sci (2020). https://doi.org/10.1007/s10072-020-04630-z
- Quality of life
- Neuro-Behçet’s disease