Quality of life in neuro-Behçet’s disease: a cross-sectional study



Behçet’s disease (BD) is a multisystemic perivasculitis with recurrent oral aphthous ulcers, genital ulcers, and eye involvement which was first described in 1937. Neurological involvement in BD patients is referred to as neuro-Behçet’s disease (NBD). Studies have shown that BD worsens quality of life. However, there is no study that conducts a head-to-head comparison of quality of life between NBD patients and healthy controls.


Forty patients with NBD and 39 age-sex-matched healthy control subjects were included in this study. Sociodemographic data of all participants were recorded; SF-36 was used to assess quality of life.


NBD patients had significantly lower SF-36 scores of physical functioning, physical difficulty, bodily pain, and general health perception compared with healthy controls. However, there was no significant difference between the groups according to the SF-36 scores of role limitation due to emotional problems, mental health, vitality, and social functioning. There was no significant difference between parenchymal and non-parenchymal NBD groups according to SF-36, Beck’s Depression Inventory, and Beck’s Anxiety Inventory scores. Patients with cerebellar system involvement had significantly lower physical and social functioning scores compared with those who did not. Patients with brain stem involvement were found to have higher role limitation due to emotional problems, vitality, social functioning, physical pain, and general health perception scores compared with those without brain stem findings.


NBD negatively affects many aspects of the quality of life.

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Data availability

All data generated or analyzed during this study are included in this published article (and its supplementary information files).


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The research was supported by ourselves.

Author information




BB and MKK analyzed and interpreted the patients’ data .MKK collected the data and was a major contributor in planning and writing the manuscript. CY contributed to the planning and manuscript writing of the study. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Müge Kuzu Kumcu.

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The authors declare that they have no conflicts of interest.

Ethical approval

The study conforms to the principles outlined in the Declaration of Helsinki. Ankara University School of Medicine clinical research ethics committee has approved the study protocols at July 27, 2015 (registrations number: 12.507.05).

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Kuzu Kumcu, M., Bakırarar, B. & Yücesan, C. Quality of life in neuro-Behçet’s disease: a cross-sectional study. Neurol Sci (2020). https://doi.org/10.1007/s10072-020-04630-z

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  • Quality of life
  • SF-36
  • Neuro-Behçet’s disease