Skip to main content

Advertisement

Log in

Optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy due to optic nerve head drusen

  • Brief Communication
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Optic nerve head drusen (ONHD) are typically benign hyaline and calcified concretions located within the optic nerve. Initially asymptomatic, they can increase slowly in size and number over time, and they can cause mechanical stress at the axons of the optic nerve and progressively lead to a loss of the visual field and papillary vascular changes. Here, we reported a rare case of a young patient with bilateral ONHD complicated by a nonarteritic anterior ischemic optic neuropathy (NAION) in the right eye. The aim of this case was to evaluate, using optical coherence tomography angiography (OCTA), the vascular network of the papillary region in both eyes in the presence of this ischemic event associated to ONHD. At OCTA examination, the whole papillary region revealed a general rarefaction of the vascular network, but it turned out to be greater in the right eye affected by nonarteritic anterior ischemic optic neuropathy than in fellow eye. Therefore, these findings demonstrated that ONHD may determine significant ischemic events of the optic nerve and OCTA represents a valid and noninvasive tool in the diagnosis and in the pathogenesis of these rare cases of NAION associated to ONHD in young patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Pinxten I, Stalmans P (2014) Radial optic neurotomy as a treatment for anterior ischemic optic neuropathy secondary to optic disc drusen. GMS Ophthalmol Cases 4:Doc05. https://doi.org/10.3205/oc000018

    Article  PubMed  PubMed Central  Google Scholar 

  2. Lam BL, Morais CG Jr, Pasol J (2008) Drusen of the optic disc. Curr Neurol Neurosci Rep 8:404–408. https://doi.org/10.1007/s11910-008-0062-6

    Article  PubMed  Google Scholar 

  3. Megur B, Megur D, Megur U, Reddy S (2014) Anterior ischemic optic neuropathy in association with optic nerve head drusen. Indian J Ophthalmol 62:829–831. https://doi.org/10.4103/0301-4738.138636

    Article  PubMed  PubMed Central  Google Scholar 

  4. Karti O, Top Karti D, Zengin MO, Yüksel B, Oguztoreli M, Kusbeci T (2018) Acute unilateral anterior ischemic optic neuropathy secondary to optic nerve head drusen: report of a rare coexistence. Neuroophthalmology 43:330–333. https://doi.org/10.1080/01658107.2018.1520900

    Article  PubMed  PubMed Central  Google Scholar 

  5. Gaier ED, Rizzo JF 3rd, Miller JB, Cestari DM (2017) Focal capillary dropout associated with optic disc drusen using optical coherence tomographic angiography. J Neuroophthalmol 37:405–410. https://doi.org/10.1097/WNO.0000000000000502

    Article  PubMed  Google Scholar 

  6. Jia Y, Tan O, Tokayer J, Potsaid B, Wang Y, Liu JJ, Kraus MF, Subhash H, Fujimoto JG, Hornegger J, Huang D (2012) Split spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express 20:4710–4725. https://doi.org/10.1364/OE.20.004710

    Article  PubMed  PubMed Central  Google Scholar 

  7. Rao HL, Pradhan ZS, Weinreb RN, Reddy HB, Riyazuddin M, Dasari S, Palakurthy M, Puttaiah NK, Rao DA, Webers CA (2016) Regional comparisons of optical coherence tomography angiography vessel density in primary open-angle glaucoma. Am J Ophthalmol 171:75–83. https://doi.org/10.1016/j.ajo.2016.08.030

    Article  PubMed  Google Scholar 

  8. Huang D, Jia Y, Gao SS, Lumbroso B, Rispoli M (2016) Optical coherence tomography angiography using the optovue device. Dev Ophthalmol 56:6–12. https://doi.org/10.1159/000442770

    Article  PubMed  Google Scholar 

  9. Newman WD, Dorrell ED (1996) Anterior ischemic optic neuropathy associated with disc drusen. J Neuroophthalmol 16:7–8

    Article  CAS  Google Scholar 

  10. Nanji AA, Klein KS, Pelak VS, Repka MX (2012) Nonarteritic anterior ischemic optic neuropathy in a child with optic disk drusen. J AAPOS 16:207–209. https://doi.org/10.1016/j.jaapos.2011.10.016

    Article  PubMed  Google Scholar 

  11. Ayhan Z, Yaman A, Söylev Bajin M, Saatci AO (2015) Unilateral acute anterior ischemic optic neuropathy in a patient with an already established diagnosis of bilateral optic disc drusen. Case Rep Ophthalmol Med 2015:730606–730604. https://doi.org/10.1155/2015/730606

    Article  PubMed  PubMed Central  Google Scholar 

  12. Martinelli V, Bianchi Marzoli S (2001) Non-demyelinating optic neuropathy: clinical entities. Neurol Sci 22(Suppl 2):S55–S59. https://doi.org/10.1007/s100720100035

    Article  PubMed  Google Scholar 

  13. Purvin V, King R, Kawasaki A, Yee R (2004) Anterior ischemic optic neuropathy in eyes with optic disc drusen. Arch Ophthalmol 122:4853–4853. https://doi.org/10.1001/archopht.122.1.48

    Article  Google Scholar 

  14. Marzoli SB, Criscuoli A (2018) Pain in optic neuropathies. Neurol Sci 39(Suppl 1):25–31. https://doi.org/10.1007/s10072-018-3334-1

    Article  PubMed  Google Scholar 

  15. Cennamo G, Tebaldi S, Amoroso F, Arvanitis D, Breve M, Cennamo G (2018) Optical coherence tomography angiography in optic nerve Drusen. Ophthalmic Res 59:76–80. https://doi.org/10.1159/000481889

    Article  PubMed  Google Scholar 

  16. Sharma S, Ang M, Najjar RP, Sng C, Cheung CY, Rukmini AV, Schmetterer L, Milea D (2017) Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol 101:1045–1051. https://doi.org/10.1136/bjophthalmol-2016-309245

    Article  PubMed  Google Scholar 

  17. Gandhi U, Chhablani J, Badakere A, Kekunnaya R, Rasheed MA, Goud A, Chhablani PP (2018) Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: a comparison with the fellow eye and with eyes with papilledema. Indian J Ophthalmol 66:1144–1148. https://doi.org/10.4103/ijo.IJO_179_18

    Article  PubMed  PubMed Central  Google Scholar 

  18. Gittinger JW Jr, Lessell S, Bondar RL (1984) Ischemic optic neuropathy associated with optic disc drusen. J Clin Neuroophthalmol 4:79–84

    PubMed  Google Scholar 

  19. Abri Aghdam K, Ashraf Khorasani M, Soltan Sanjari M, Habibi A, Shenazandi H, Kazemi P, Ghasemi Falavarjani K (2019) Optical coherence tomography angiography features of optic nerve head drusen and nonarteritic anterior ischemic optic neuropathy. Can J Ophthalmol 54:495–500. https://doi.org/10.1016/j.jcjo.2018.08.002

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gilda Cennamo.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cennamo, G., Montorio, D., Giunta, P. et al. Optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy due to optic nerve head drusen. Neurol Sci 41, 3349–3351 (2020). https://doi.org/10.1007/s10072-020-04493-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-020-04493-4

Keywords

Navigation