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STK11 mutation status is associated with decreased survival in meningiomas

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Abstract

Background

Emerging evidence suggests that STK11 mutations may influence clinical outcome and response to immunotherapy in cancer.

Materials and methods

Next-generation targeted sequencing of STK11 mutation status in a large cohort of 188 meningiomas.

Results

STK11 loss-of-function mutations were identified in 3.7% of meningiomas. STK11 mutations were found in both low- and high-grade lesions and samples from primary and recurrent disease. There was a 2.8-fold increased risk of death for patients whose meningioma harbored an STK11 mutation, after controlling for lesion grade and occurrence status. The median overall survival for patients with STK11-mutated meningiomas was 4.4 years compared with 16.8 years.

Conclusion

These data identify recurrent STK11 mutations in a subset of meningiomas. Genotyping of STK11 is encouraged for meningioma patients undergoing immunotherapy-based therapy.

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Authors and Affiliations

  1. Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA

    Corey M. Gill, Joshua Loewenstern, John W. Rutland, Margaret Pain, Joshua Bederson & Raj K. Shrivastava

  2. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Hanane Arib & Robert Sebra

  3. Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Melissa Umphlett, Yayoi Kinoshita, Russell B. McBride, Michael Donovan & Mary Fowkes

  4. The Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Russell B. McBride

  5. Sema4, A Mount Sinai Venture, Stamford, CT, USA

    Robert Sebra

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  1. Corey M. Gill
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Correspondence to Corey M. Gill.

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This study was reviewed and approved by the human subjects’ institutional review board and complied with HIPAA (Health Insurance Portability and Accountability Act of 1996) guidelines. Informed consent was waived.

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Gill, C.M., Loewenstern, J., Rutland, J.W. et al. STK11 mutation status is associated with decreased survival in meningiomas. Neurol Sci 41, 2585–2589 (2020). https://doi.org/10.1007/s10072-020-04372-y

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  • DOI: https://doi.org/10.1007/s10072-020-04372-y

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