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Structural remodeling secondary to functional remodeling in advanced-stage peripheral facial neuritis

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Abstract

Background

Structural remodeling is a classic manifestation of disease decompensation. Facial synkinesis is the most troubling sequela of peripheral facial neuritis, and its structural remodeling, especially in white matter (WM), is still poorly understood. Therefore, understanding WM microstructure is important for predicting WM pathology and for early intervention in facial synkinesis patients.

Methods

A total of 20 facial synkinesis patients (18 men and 2 women; mean age, 33.35 ± 6.97 years old) and 19 healthy controls (17 men and 2 women; mean age, 33.21 ± 6.75 years old) were enrolled in this study. rs-fMRI data, diffusion tensor imaging (DTI) data, and Beck’s Depression Inventory (BDI) data were collected, and tract-based spatial statistics (TBSS) and voxel-mirrored homotopic connectivity (VMHC) values were used to analyze changes in WM microstructure and interhemispheric coordination.

Results

Compared with the healthy controls, facial synkinesis patients exhibited significantly lower regional fractional anisotropy (FA) in the genu of the corpus callosum and the body of the corpus callosum, significantly higher regional FA in the retrolenticular part of the internal capsule, and significantly decreased VMHC values bilaterally in the orbital inferior frontal gyri, the fusiform gyri, the superior temporal gyri, the superior frontal gyri, and the supplementary motor areas. Furthermore, a lower regional FA in the genu of the corpus callosum was correlated with higher BDI scores in facial synkinesis patients.

Conclusion

Structural remodeling, especially changes in white matter microstructure, may be the central mechanism for severe sequelae of peripheral facial neuritis.

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Data availability

The data that support the findings of this study are available from the corresponding author, Jian-guang Xu, upon reasonable request.

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Funding

This work was supported by the National Key R&D Program of China (Grant No. 2018YFC2001600), the Shanghai Science and Technology Committee (Grants 18511108300, 18441903903900, and 18441903800), and the Shanghai Jiaotong University Multidisciplinary Research Fund of Medicine and Engineering (YG 2016QN13).

Author information

Author notes

  1. Jie Ma, Xu-Yun Hua and Mou-Xiong Zheng contributed equally to this work.

Authors and Affiliations

  1. School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Jie Ma, Xu-Yun Hua, Bei-Bei Huo, Xiang-Xin Xing & Jian-Guang Xu

  2. Department of Traumatology and Orthopedics, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Xu-Yun Hua & Mou-Xiong Zheng

  3. Spine Surgery Division of Department of Orthopedics, Rehabilitation Section, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China

    Xu-Yun Hua

  4. Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Tongji University, Ministry of Education of the People’s Republic of China, Shanghai, China

    Xu-Yun Hua

  5. Center of Rehabilitation Medicine, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Jia-Jia Wu & Jian-Guang Xu

  6. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

    Wei Ding

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  1. Jie Ma
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Correspondence to Wei Ding or Jian-Guang Xu.

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The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the local ethics committee at the Ninth People's Hospital  (approval no. 2017-365-T267), and all patients provided written informed consent according to the Helsinki Declaration.

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Ma, J., Hua, XY., Zheng, MX. et al. Structural remodeling secondary to functional remodeling in advanced-stage peripheral facial neuritis. Neurol Sci 41, 2453–2460 (2020). https://doi.org/10.1007/s10072-020-04325-5

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