Abstract
Gait and posture parameters of ten advanced Parkinson’s disease (PD) patients were assessed before and after starting levodopa-carbidopa intestinal gel (LCIG) treatment by means of both objective video analysis and clinical assessment. After 3 years of treatment, gait and posture remained stable. A slower gait velocity at baseline significantly correlates with a higher axial and motor severity at follow-up. This pilot study suggests that validated video analysis software may support the clinical assessment of axial signs in PD patients who are candidates for device-aided therapies.
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The authors thank all the patients and their families for participating in this study.
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Dr. Margherita Fabbri: no conflict of interest to report. Stock ownership in medically related fields: none. Consultancies: none. Advisory boards: none. Partnership: none. Honoraria to speak: none. Grants: AbbVie. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none
Chatkaew Pongmala: no conflict of interest to report. Stock ownership in medically related fields: none. Consultancies: none. Advisory boards: none. Partnership: none. Honoraria to speak: none. Grants: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none
Dr. Carlo Alberto Artusi: no conflict of interest to report. Stock ownership in medically related fields: none. Honoraria to speak and grants: Neuraxpharm, Zanbom, and AbbVie. Advisory boards: none. Partnership: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none
Dr. Gabriele Imbalzano: no conflict of interest to report. Stock ownership in medically related fields: none. Honoraria to speak and grants: none. Advisory boards: none. Partnership: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none
Dr. Alberto Romagnolo: no conflict of interest to report. Grant support and speaker honoraria from AbbVie and speaker honoraria from Chiesi Farmaceutici and travel grants from Lusofarmaco, Chiesi, Medtronic, and UCB Pharma. Expert testimony: none. Contracts: none. Royalties: none. Other: none
Prof. Leonardo Lopiano: no conflict of interest to report. Stock Ownership in medically related fields: none. Honoraria to speak and grants: Medtronic, UCB Pharma, AbbVie, and Doc Generici. Advisory boards: none. Partnership: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none
Dr. Maurizio Zibetti: no conflict of interest to report. Stock Ownership in medically related fields: none. Honoraria to speak and grants: Medtronic, Lundbeck, UCB Pharma, and AbbVie. Advisory boards: none. Partnership: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none
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Fabbri, M., Pongmala, C., Artusi, C.A. et al. Video analysis of long-term effects of levodopa-carbidopa intestinal gel on gait and posture in advanced Parkinson’s disease. Neurol Sci 41, 1927–1930 (2020). https://doi.org/10.1007/s10072-020-04319-3
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DOI: https://doi.org/10.1007/s10072-020-04319-3