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Prognostic role of Mini-Mental State Pediatric Examination (MMSPE) on neuropsychological functioning



The aim of this study was to evaluate the ability of the Mini-Mental State Pediatric Examinations (MMSPE) in the individuation of neuropsychological impairments.


MMSPE was administered to 60 children attending a primary or lower secondary school suffering from neurological diseases, admitted to our neuropsychology services. All children performed both a MMSPE examination and a neuropsychological evaluation. Results of neuropsychological evaluation and MMSPE were dichotomized. Positive predictive value (PPV), negative predictive value (NPV), and accuracy were also calculated.


The diagnostic performance of MMSPE showed a good overall accuracy (0.83, CI 95% 0.64–0.91), NPV (0.81, CI 95% 0.73–1.00), PPV (0.87, CI 95% 0.68–0.94), specificity (0.91, CI 95% 0.81–1.00), sensitivity (0.74, CI 95% 0.57–0.90), and odds ratio of 28.5 (CI 95% 6.6–123), p < 0.001.


MMSPE has a good prognostic ability in predicting neuropsychological problems in the context of different neurological pediatric diseases. We suggest that this instrument could greatly improve pediatric clinical practice in identifying high-risk children.

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Correspondence to Elisa Cainelli.

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The Institutional Review Board of our Department approved our study and parents of children recruited gave informed consent.

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Cainelli, E., Di Giacomo, D.L., Mantegazza, G. et al. Prognostic role of Mini-Mental State Pediatric Examination (MMSPE) on neuropsychological functioning. Neurol Sci 41, 619–623 (2020).

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  • Screening
  • Cognitive
  • Children
  • Clinical practice
  • Predictive