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Dementia trajectory for patients with logopenic variant primary progressive aphasia

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Abstract

Background

The timing of progression of logopenic variant primary progressive aphasia (lvPPA) to severe dementia has not been elucidated. To address this shortcoming, 10 patients with lvPPA were continuously followed.

Methods

Patients were assessed with the annual rate of change in the Clinical Dementia Rating (CDR) sum of boxes and period from lvPPA onset to the onset of benchmark signs, including mild, moderate, or severe dementia, episodic memory deficits, topographical disorientation, difficulties with using controls for electronic appliances, and conceptual apraxia. When severe dementia was evident, we also investigated the incidence of severe cognitive and behavioral signs such as neologistic jargon, difficulties in recognizing family members, pica, and mirror sign.

Results

The mean time for patients to reach a particular CDR was as follows: CDR of 1, 4.1 ± 1.3 years post-onset; CDR 2, 5.7 ± 1.6 years; CDR 3, 7.3 ± 1.6 years. The annual rate of change in the CDR sum of boxes was 3.4 ± 1.1, corresponding to 1.7 years for the CDR to increase by 1.0. Difficulties with using electronic controls began at 3.3 ± 1.6 years, episodic memory deficits at 4.0 ± 2.0 years, topographical disorientation at 5.2 ± 2.1 years, and conceptual apraxia at 5.5 ± 2.1 years. For patients who progressed to severe dementia, six could not recognize family members, five exhibited pica, three experienced mirror sign, and one developed neologistic jargon.

Conclusions

Our results suggest that patients with lvPPA progress rapidly to dementia and develop conceptual apraxia, episodic memory deficits, visuospatial deficits, and semantic memory deficits.

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Acknowledgments

We thank the patients and their caregivers who participated in this study.

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Authors and Affiliations

  1. Department of Neuropsychiatry, Ashikaga Red Cross Hospital, Ashikaga, Tochigi, 3260843, Japan

    Michitaka Funayama, Taketo Takata & Yu Mimura

  2. Department of Rehabilitation, Edogawa Hospital, Tokyo, 1330052, Japan

    Yoshitaka Nakagawa

  3. Department of Rehabilitation, Ashikaga Red Cross Hospital, Ashikaga, Tochigi, 3260843, Japan

    Asuka Nakajima

  4. Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 1608582, Japan

    Masaru Mimura

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  1. Michitaka Funayama
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  2. Yoshitaka Nakagawa
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  4. Taketo Takata
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Contributions

MF, YN, TT, YM, and AN acquired case data. MF designed the study, and drafted the manuscript. MM supervised the study.

Corresponding author

Correspondence to Michitaka Funayama.

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The authors declare that they have no competing interests.

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Informed consent was obtained from each patient and/or their spouse.

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Aspects of the study concerning ethics were approved by the Human Research Ethics Committee of Ashikaga Red Cross Hospital.

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Funayama, M., Nakagawa, Y., Nakajima, A. et al. Dementia trajectory for patients with logopenic variant primary progressive aphasia. Neurol Sci 40, 2573–2579 (2019). https://doi.org/10.1007/s10072-019-04013-z

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  • DOI: https://doi.org/10.1007/s10072-019-04013-z

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