Skip to main content
SpringerLink
Log in

Seronegative limbic encephalitis

Neurological Sciences volume 41, pages 205–208 (2020)Cite this article

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Fig. 1
Fig. 2

References

  1. Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, Cortese I, Dale RC, Gelfand JM, Geschwind M, Glaser CA, Honnorat J, Höftberger R, Iizuka T, Irani SR, Lancaster E, Leypoldt F, Prüss H, Rae-Grant A, Reindl M, Rosenfeld MR, Rostásy K, Saiz A, Venkatesan A, Vincent A, Wandinger KP, Waters P, Dalmau J (2016) A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol 15:391–404

    Article  Google Scholar 

  2. Graus F, Escudero D, Oleaga L, Bruna J, Villarejo-Galende A, Ballabriga J, Barceló MI, Gilo F, Popkirov S, Stourac P, Dalmau J (2018) Syndrome and outcome of antibody-negative limbic encephalitis. Eur J Neurol 25:1011–1016

    Article  CAS  Google Scholar 

  3. Steriade C, Moosa ANV, Hantus S, Prayson RA, Alexopoulos A, Rae-Grant A (2018) Electroclinical features of seizures associated with autoimmune encephalitis. Seizure. 60:198–204

    Article  Google Scholar 

  4. López-Chiriboga AS, Flanagan EP (2018) Diagnostic and therapeutic approach to autoimmune neurologic disorders. Semin Neurol 38:392–402

    Article  Google Scholar 

  5. Zuliani L, Nosadini M, Gastaldi M, Spatola M, Iorio R, Zoccarato M, Mariotto S, de Gaspari P, Perini F, Ferrari S, Evoli A, Sartori S, Franciotta D, Giometto B (2019) Management of antibody-mediated autoimmune encephalitis in adults and children: literature review and consensus-based practical recommendations. Neurol Sci 3. https://doi.org/10.1007/s10072-019-03930-3

    Article  Google Scholar 

  6. van Sonderen A, Petit-Pedrol M, Dalmau J, Titulaer MJ (2017) The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis. Nat Rev Neurol 13:290–301

    Article  Google Scholar 

Download references

Acknowledgments

We thank Alexandra L. Salewski, MSc, for the English revision of the manuscript.

Author information

Authors and Affiliations

  1. Servicio de Neurología, Complejo Hospitalario Universitario de Albacete, E-02008, Albacete, Spain

    Álvaro Sánchez-Larsen

  2. Departmento de Investigación, Unidad de Neuropsicofarmacología, Complejo Hospitalario Universitario de Albacete, E-02008, Albacete, Spain

    Carlos de Cabo

Authors
  1. Álvaro Sánchez-Larsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carlos de Cabo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carlos de Cabo.

Ethics declarations

All examinations and interventions were performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki (amended version from 2013) and complemented by the Declaration of Taipei on Ethical Considerations regarding Health Databases and Biobanks in 2016.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Suppl. Fig. 1

LTS. Left temporal seizure. Legend: Longitudinal bipolar montage, sensitivity 10uV/mm, timebase 15mm/s, LFF 1 Hz, HFF 15 Hz. Seizure starts with a spike-and-wave in left temporal electrodes, T3>T5-F7 (red arrow) followed by a low-amplitude spiky activity that evolves into a lobar spike-and-wave pattern on delta range in left temporal. Seizure subsequently propagates to the right temporal lobe with an (asymmetric, left more than right) bitemporal high amplitude polyspikes on alfa range, that progressively increases in amplitude and decreases in frequency, finalizing abruptly (red discontinuous line). The patient did not refer symptoms, but piloerection in left arm and facial flushing was observed in the physical exploration during seizure. (JPG 1162 kb)

Suppl. Fig. 2.

RTS. Subclinical right temporal seizure: Legend: Longitudinal bipolar montage, sensitivity 10uV/mm, timebase 15mm/s, LFF 0.5 Hz, HFF 15 Hz. Seizure starts in right anterior-temporal electrodes F8>T4 (red arrow) with a spiky incremental theta activity that progressively increases in amplitude. The seizure remains limited to anterior-temporal electrodes without propagation to adjacent regions. The patient had no symptoms and physical exploration was normal during the seizure. (JPG 470 kb)

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sánchez-Larsen, Á., de Cabo, C. Seronegative limbic encephalitis. Neurol Sci 41, 205–208 (2020). https://doi.org/10.1007/s10072-019-04011-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-019-04011-1

search

Navigation