Skip to main content

Advertisement

Log in

Knuckle pigmentation, peripheral neuropathy, madness and abnormal movement: is it B12 deficiency?

  • Letter to the Editor
  • Published:
Neurological Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Abbreviations

MCV:

mean corpuscular volume

ESR:

erythrocyte sedimentation rate

ANA:

anti-nuclear antibody

SEP:

somatosensory-evoked potential

EEG:

electroencephalogram

MRI:

magnetic resonance imaging

MMSE:

mini mental state examination

References

  1. Aaron S, Kumar S, Vijayan J, Jacob J, Alexander M, Gnanamuthu C (2005) Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency related neurological syndromes. Neurol India 53(1):55–58

    Article  CAS  Google Scholar 

  2. Agrawala R, Sahoo S, Choudhury A, Mohanty B, Baliarsinha A (2013) Pigmentation in vitamin B12 deficiency masquerading Addison’s pigmentation: a rare presentation. Indian J Endocrinol Metab 17(7):254

    Article  Google Scholar 

  3. Jadhav M, Webb JKG, Vaishnava S, Baker SJ (1962) Vitamin-B12 deficiency in Indian infants. Lancet 2:903–907

    Article  CAS  Google Scholar 

  4. Grattan-Smith PJ, Wileken B, Procopis PG, Wise GA (1997) The neurological syndrome of infantile cobalamin deficiency: developmental regression and involuntary movements. Mov Disord 12:39–46

    Article  CAS  Google Scholar 

  5. Celik M, Barkut IK, Oncel C, Forta H (2003) Involuntary movements associated with vitamin B12 deficiency. Parkinsonism Relat Disord 10(1):55–57

    Article  Google Scholar 

  6. Andrès E, Serraj K, Zhu J, Vermorken AJ (2013) The pathophysiology of elevated vitamin B12 in clinical practice. QJM. 106:505–515

    Article  Google Scholar 

Download references

Acknowledgements

We thank Mr. Divendu Deewan for technical help.

Author information

Authors and Affiliations

Authors

Contributions

SKB: study concept, data acquisition, manuscript writing and critical reviewing

MJ: data acquisition and patient management

SN: data acquisition, manuscript writing and critical reviewing

GDP: data acquisition and patient management

Corresponding author

Correspondence to Sanjeev Kumar Bhoi.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from the patient included in the study. “Additional informed consent was obtained the patient for whom identifying information is included in this article.”

Research involving human participants and/or animals

For this type of study (case report), formal consent is not required.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bhoi, S.K., Jha, M., Naik, S. et al. Knuckle pigmentation, peripheral neuropathy, madness and abnormal movement: is it B12 deficiency?. Neurol Sci 40, 2399–2401 (2019). https://doi.org/10.1007/s10072-019-03918-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-019-03918-z

Navigation