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Regional cerebral blood flow correlates eating abnormalities in frontotemporal dementia

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Abstract

Background

Eating abnormalities are one of the core symptoms of frontotemporal dementia (FTD), especially for behavioral variant FTD (bvFTD), and semantic variant primary progressive aphasia (svPPA).

Methods

A group of FTD patients (43 bvFTD, 29 svPPA) underwent single-photon emission CT (SPECT) to measure the region cerebral blood flow (rCBF). The Cambridge Behavioral Inventory (CBI) was used to measure the eating abnormalities. A whole-brain voxel-based correlation between eating abnormalities and rCBF was investigated.

Results

In bvFTD, the sweet preference was correlated with decreased rCBF in the bilateral gyrus rectus and temporal pole, and eating the same food was correlated with the left ventral anterior cingulate cortex. In svPPA, decreased rCBF in the left inferior temporal gyrus was correlated with eating the same food.

Conclusions

These findings showed that either different symptoms in the same subtype or the same symptom in different subtypes of FTD may be correlated with different regions, indicating different neural mechanisms behind them.

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Author notes

  1. Zhi Zhou and Xudong Li contributed equally to this work.

Authors and Affiliations

  1. Department of Geriatrics, China-Japan Friendship Hospital, 2 Yinghuayuan Dongjie, Beijing, 100029, China

    Zhi Zhou & Xiaoyun Zheng

  2. Department of Cognitive Disorder, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Xudong Li

  3. China National Clinical Research Center for Neurological Diseases, Beijing, China

    Xudong Li

  4. Department of Neurology, China-Japan Friendship Hospital, Beijing, China

    Yi Jin, Shuhong Jia & Jinsong Jiao

  5. Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing, China

    Yumin Zheng

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  1. Zhi Zhou
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  2. Xudong Li
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Correspondence to Xiaoyun Zheng.

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This study was approved by the China-Japan Friendship Hospital, and study procedures were followed in accordance with the ethical standards of the hospital. Written informed consent was obtained from all of the subjects prior to any study procedures.

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Zhou, Z., Li, X., Jin, Y. et al. Regional cerebral blood flow correlates eating abnormalities in frontotemporal dementia. Neurol Sci 40, 1695–1700 (2019). https://doi.org/10.1007/s10072-019-03910-7

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  • DOI: https://doi.org/10.1007/s10072-019-03910-7

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