A fatal back pain: report of two cases of diffuse large B cell/Burkitt-like nervous system lymphoma
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Primary central nervous system lymphoma (PCNSL) is an uncommon variant of the extranodal non-Hodgkin lymphoma which involves different structures of the nervous system. It accounts for 2.7% of all nervous system malignancies . Most PCNSL are diffuse large B cell lymphomas (DLBCLs). Diffuse large B cell lymphoma/Burkitt-like (DLBCL/BL) is a term assigned to an aggressive B cell lymphoma with features intermediate between the diffuse large B cell lymphoma and the Burkitt-like lymphoma in the updated WHO classification of tumors of the hematopoietic and lymphoid tissues . There are no data on the incidence and prognosis of the nervous system DLBCL/BL since there has been only one report of DLBCL/BL with cerebral and involvement of the cauda equina which suggested DLBCL/BL could be PCNSL with a very aggressive nature . We present a case of PCNSL and a case of primary lymphoma of peripheral nerve (PLPN), both DBCL/BL, with an initial presentation as lower...
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Informed consent was obtained from both patients included in this paper.
Conflict of interest
The authors declare that they have no conflict of interest.
- 2.Swerdlow S, Campo E, Harris N, Jaffe E, Pileri S, Stein H, Thiele J, Vardiman J (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edition, World Health OrganizationGoogle Scholar
- 3.Jiang L, Li Z, Finn LE, Personnet DA, Edenfield B, Foran JM, Jaeckle KA, Reimer R, Menke DM, Ketterling RP, Tun HW (2012) Primary central nervous system B cell lymphoma with features intermediate between diffuse large B cell lymphoma and Burkitt lymphoma. Int J Clin Exp Pathol 5(1):72–76PubMedPubMedCentralGoogle Scholar
- 5.Del Grande A, Sabatelli M, Luigetti M, Conte A, Granata G, Rufini V, Del Ciello A, Gaudino S, Fernandez E, Hohaus S, Coli A, Lauriola L (2014) Primary multifocal lymphoma of peripheral nervous system: case report and review of the literature. Muscle Nerve 50(6):1016–1022. https://doi.org/10.1002/mus.24354 CrossRefPubMedGoogle Scholar