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Subjective cognitive decline: preclinical manifestation of Alzheimer’s disease

Neurological Sciences volume 40, pages 41–49 (2019)Cite this article

Abstract

Subjective cognitive decline (SCD), characterized by a very early and subtle cognitive decline prior to the appearance of objective cognitive impairment, is considered to be the preclinical manifestation of Alzheimer’s disease (AD). Given the lack of significant abnormalities in standardized neuropsychological assessments for individuals with SCD, biochemical and neuroimaging biomarkers may be important indicators of the preclinical stage of AD. The application of various biomarkers derived from the cerebrospinal fluid and neuroimaging thus has the potential to make AD-related pathology detectable in vivo. In this review, we discuss the conceptual evolution of SCD as an entity and further elucidate characteristic cerebrospinal fluid and neuroimaging biomarkers of SCD.

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Funding

This work was supported by grants from the National Science Foundation for Young Scientists of China (No. 81100972) and Science and Technology Planning Project of Shandong Province (No. 2012GSF12120).

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  1. Can Sheng and Lin Ma contributed equally to this work.

Affiliations

  1. Department of Neurology, Qilu Hospital of Shandong University, Jinan, 250012, China

    Yan Lin

  2. Department of Gerontology, Qilu Hospital of Shandong University, Jinan, 250012, China

    Pei-Yan Shan, Wen-Jing Jiang & Lin Ma

  3. Department of Neurology, the First Hospital of Tsinghua University, Beijing, 100016, China

    Can Sheng

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  1. Yan Lin
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Lin, Y., Shan, PY., Jiang, WJ. et al. Subjective cognitive decline: preclinical manifestation of Alzheimer’s disease. Neurol Sci 40, 41–49 (2019). https://doi.org/10.1007/s10072-018-3620-y

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Keywords

  • Subjective cognitive decline
  • Alzheimer’s disease
  • Preclinical
  • Biomarkers
  • Neuroimaging