Neurological Sciences

, Volume 39, Issue 8, pp 1459–1462 | Cite as

Orthostatic hypotension acutely impairs executive functions in Parkinson’s disease

  • Michela Sforza
  • Francesca Assogna
  • Domiziana Rinaldi
  • Giuliano Sette
  • Stefania Tagliente
  • Francesco E. Pontieri
Brief Communication


Orthostatic hypotension is a frequent non-motor symptom of Parkinson’s disease, with negative prognostic role on cognitive functions. Here we measured the acute effects of orthostatic hypotension on executive functions in Parkinson’s disease patients devoid of hypertension, carotid artery stenosis, and significant chronic cerebrovascular pathology. Measurements were carried out during regular visits in outpatient setting. Twenty-eight Parkinson’s disease patients were recruited and studied along scheduled outpatient visits. They were divided into two groups (n = 14 each) based on the presence or lack of orthostatic hypotension. This was diagnosed according to international guidelines. All patients were submitted to the Stroop’s test and to the phonological and semantic verbal fluency test after 10-min resting in supine position and immediately upon standing in upright position. Testing lasted less than 5 min in either position. In upright position, subjects with orthostatic hypotension displayed significantly worse performances at the Stroop’s test word reading time (22.1 ± 4.1 vs. 14.9 ± 4.0 s), interference time (56.1 ± 12.3 vs. 41.4 ± 11.8 s), and number of errors at the interference section (5.8 ± 3.2 vs. 1.3 ± 2.1) as compared to those without orthostatic hypotension. These results demonstrate that worsening of attentive function upon standing can be measured in Parkinson’s disease patients with orthostatic hypotension during routine outpatient visits. These findings suggest that clinically asymptomatic orthostatic hypotension in Parkinson’s disease patients may acutely worsen neuropsychological performances with possible negative impact on daily functioning.


Cognition Executive functions Orthostatic hypotension Parkinson’s disease 


Compliance with ethical standards

The protocol was approved by the Ethical Committee of the “Fondazione Santa Lucia, IRCCS,” and each subject signed informed consent.

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Dipartimento di Neuroscienze, Salute Mentale e Organi di Senso“Sapienza” Università di RomaRomeItaly
  2. 2.Museo Storico della Fisica e Centro Studi e Ricerche “Enrico Fermi”RomeItaly
  3. 3.Dipartimento di Neurologia Clinica e ComportamentaleIRCCS “Fondazione Santa Lucia”RomeItaly

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