Skip to main content


Log in

Establishment of an Italian chronic migraine database: a multicenter pilot study

  • Brief Communication
  • Published:
Neurological Sciences Aims and scope Submit manuscript


To optimize chronic migraine (CM) ascertainment and phenotype definition, provide adequate clinical management and health care procedures, and rationalize economic resources allocation, we performed an exploratory multicenter pilot study aimed at establishing a CM database, the first step for developing a future Italian CM registry. We enrolled 63 consecutive CM patients in four tertiary headache centers screened with face-to-face interviews using an ad hoc dedicated semi-structured questionnaire gathering detailed information on life-style, behavioral and socio-demographic factors, comorbidities, and migraine features before and after chronicization and healthcare resource use. Our pilot study provided useful insights revealing that CM patients (1) presented in most cases symptoms of peripheral trigeminal sensitization, a relatively unexpected feature which could be useful to unravel different CM endophenotypes and to predict trigeminal-targeted treatments’ responsiveness; (2) had been frequently admitted to emergency departments; (3) had undergone, sometime repeatedly, unnecessary or inappropriate investigations; (4) got rarely illness benefit exemption or disability allowance only. We deem that the expansion of the database—shortly including many other Italian headache centers—will contribute to more precisely outline CM endophenotypes, hence improving management, treatment, and economic resource allocation, ultimately reducing CM burden on both patients and health system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.


  1. Headache Classification Committee of the International Headache Society (IHS) (2013) The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808

    Article  Google Scholar 

  2. Diener HC, Dodick DW, Goadsby PJ, Lipton RB, Olesen J, Silberstein SD (2012) Chronic migraine—classification, characteristics and treatment. Nat Rev Neurol 8(3):162–171.

    Article  CAS  PubMed  Google Scholar 

  3. Mitsikostas DD, Reuter U (2017) Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: comparisons across randomized controlled studies. Curr Opin Neurol 30(3):272–280.

    Article  CAS  PubMed  Google Scholar 

  4. Silberstein SD, Lipton RB, Dodick DW (2014) Operational diagnostic criteria for chronic migraine: expert opinion. Headache 54(7):1258–1266.

    Article  PubMed  Google Scholar 

  5. GBD (2016) Disease and injury incidence and prevalence collaborators (2017) global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390(10100):1211–1259.

    Google Scholar 

  6. Barbanti P, Egeo G (2015) Pharmacological trials in migraine: it’s time to reappraise where the headache is and what the pain is like. Headache 55(3):439–441.

    Article  PubMed  Google Scholar 

  7. Barbanti P, Ferroni P (2017) Onabotulinum toxin A in the treatment of chronic migraine: patient selection and special considerations. J Pain Res 10:2319–2329. eCollection 2017

    Article  PubMed  PubMed Central  Google Scholar 

  8. Barbanti P, Aurilia C, Fofi L, Egeo G, Ferroni P (2017) The role of anti-CGRP antibodies in the pathophysiology of primary headaches. Neurol Sci 38(Suppl 1):31–35.

    Article  PubMed  Google Scholar 

  9. Jameson JL, Longo DL (2015) Precision medicine—personalized, problematic, and promising. N Engl J Med 372(23):2229–2234.

    Article  CAS  PubMed  Google Scholar 

  10. Manack A, Buse DC, Serrano D, Turkel CC, Lipton RB (2011) Rates, predictors, and consequences of remission from chronic migraine to episodic migraine. Neurology 76(8):711–718.

    Article  CAS  PubMed  Google Scholar 

Download references


Thanks are due to Dr. Silvia Riondino for English revision.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Piero Barbanti.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Barbanti, P., Fofi, L., Cevoli, S. et al. Establishment of an Italian chronic migraine database: a multicenter pilot study. Neurol Sci 39, 933–937 (2018).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: