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Establishment of an Italian chronic migraine database: a multicenter pilot study

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Abstract

To optimize chronic migraine (CM) ascertainment and phenotype definition, provide adequate clinical management and health care procedures, and rationalize economic resources allocation, we performed an exploratory multicenter pilot study aimed at establishing a CM database, the first step for developing a future Italian CM registry. We enrolled 63 consecutive CM patients in four tertiary headache centers screened with face-to-face interviews using an ad hoc dedicated semi-structured questionnaire gathering detailed information on life-style, behavioral and socio-demographic factors, comorbidities, and migraine features before and after chronicization and healthcare resource use. Our pilot study provided useful insights revealing that CM patients (1) presented in most cases symptoms of peripheral trigeminal sensitization, a relatively unexpected feature which could be useful to unravel different CM endophenotypes and to predict trigeminal-targeted treatments’ responsiveness; (2) had been frequently admitted to emergency departments; (3) had undergone, sometime repeatedly, unnecessary or inappropriate investigations; (4) got rarely illness benefit exemption or disability allowance only. We deem that the expansion of the database—shortly including many other Italian headache centers—will contribute to more precisely outline CM endophenotypes, hence improving management, treatment, and economic resource allocation, ultimately reducing CM burden on both patients and health system.

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References

  1. Headache Classification Committee of the International Headache Society (IHS) (2013) The international classification of headache disorders, 3rd edition (beta version). Cephalalgia 33:629–808

    Article  Google Scholar 

  2. Diener HC, Dodick DW, Goadsby PJ, Lipton RB, Olesen J, Silberstein SD (2012) Chronic migraine—classification, characteristics and treatment. Nat Rev Neurol 8(3):162–171. https://doi.org/10.1038/nrneurol.2012.13

    Article  CAS  PubMed  Google Scholar 

  3. Mitsikostas DD, Reuter U (2017) Calcitonin gene-related peptide monoclonal antibodies for migraine prevention: comparisons across randomized controlled studies. Curr Opin Neurol 30(3):272–280. https://doi.org/10.1097/WCO.0000000000000438

    Article  CAS  PubMed  Google Scholar 

  4. Silberstein SD, Lipton RB, Dodick DW (2014) Operational diagnostic criteria for chronic migraine: expert opinion. Headache 54(7):1258–1266. https://doi.org/10.1111/head.12407

    Article  PubMed  Google Scholar 

  5. GBD (2016) Disease and injury incidence and prevalence collaborators (2017) global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390(10100):1211–1259. https://doi.org/10.1016/S0140-6736(17)32154-2

    Google Scholar 

  6. Barbanti P, Egeo G (2015) Pharmacological trials in migraine: it’s time to reappraise where the headache is and what the pain is like. Headache 55(3):439–441. https://doi.org/10.1111/head.12498

    Article  PubMed  Google Scholar 

  7. Barbanti P, Ferroni P (2017) Onabotulinum toxin A in the treatment of chronic migraine: patient selection and special considerations. J Pain Res 10:2319–2329. https://doi.org/10.2147/JPR.S113614 eCollection 2017

    Article  PubMed  PubMed Central  Google Scholar 

  8. Barbanti P, Aurilia C, Fofi L, Egeo G, Ferroni P (2017) The role of anti-CGRP antibodies in the pathophysiology of primary headaches. Neurol Sci 38(Suppl 1):31–35. https://doi.org/10.1007/s10072-017-2907-8

    Article  PubMed  Google Scholar 

  9. Jameson JL, Longo DL (2015) Precision medicine—personalized, problematic, and promising. N Engl J Med 372(23):2229–2234. https://doi.org/10.1056/NEJMsb1503104

    Article  CAS  PubMed  Google Scholar 

  10. Manack A, Buse DC, Serrano D, Turkel CC, Lipton RB (2011) Rates, predictors, and consequences of remission from chronic migraine to episodic migraine. Neurology 76(8):711–718. https://doi.org/10.1212/WNL.0b013e31820d8af2

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Thanks are due to Dr. Silvia Riondino for English revision.

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Correspondence to Piero Barbanti.

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Barbanti, P., Fofi, L., Cevoli, S. et al. Establishment of an Italian chronic migraine database: a multicenter pilot study. Neurol Sci 39, 933–937 (2018). https://doi.org/10.1007/s10072-018-3280-y

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  • DOI: https://doi.org/10.1007/s10072-018-3280-y

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