Neurological Sciences

, Volume 39, Issue 4, pp 691–698 | Cite as

Association of MTHFR gene polymorphisms with migraine in North Indian population

  • Sukhvinder Kaur
  • Arif Ali
  • Anil Kumar Pandey
  • Balkirat Singh
Original Article

Abstract

Polymorphisms in MTHFR gene are mostly associated with increased levels of homocysteine in the absence of dietary folate and are a risk factor for complex neurovascular diseases like migraine. The aim of present case-control study was to determine the association between MTHFR gene polymorphisms (C667T; rs 1801133, A1298C; rs 1801131) with migraine susceptibility. In total, 100 patients with migraine (23with MA and 77 with MO) and age-sex matched 100 healthy controls were included in this study from OPD of ESIC Medical College & Hospital, Faridabad. Genotyping was done by PCR-RFLP method. Genotypic and allelic frequencies were compared by SPSS 24 version. Genotypic results indicated a non-significant increase in frequencies of CT and TT in C667T SNP in migraine patients with control (52 and 10% vs. 42 and 7%: p > 0.05), but CC genotype in A1298C was found to be a risk factor in migraine patients than controls (30 vs. 17% respectively: p < 0.05). On comparing migraine subclasses, migraine with aura (MA) and without aura (MO) with control groups, the present study suggests that in MTHFR polymorphisms, the prevalence of 677CT genotype and T allele in C667T SNP influences susceptibility to MA (p < 0.05) but not to MO. Meanwhile, CC genotype in A1298C SNP could be a risk factor for migraine patients without aura (p < 0.05).

Keywords

Migraine MTHFR gene rs 1801133 rs 1801131 Single nucleotide polymorphisms 

Notes

Acknowledgements

The authors sincerely thank Dr. Praveen Malik of ESIC Medical College & Hospital, Faridabad, India, for providing samples. Financial support from UGC, New Delhi, India, to Sukhvinder kaur as a UGC-PDF is also highly acknowledged.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of BiosciencesUGC-PDF, Gene Expression LabNew DelhiIndia
  2. 2.Department of BiosciencesUGC-BSR-FFNew DelhiIndia
  3. 3.Department of PhysiologyESIC Medical College & HospitalFaridabadIndia
  4. 4.NC Medical College & HospitalPanipatIndia

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