Seizure as the unique clinical manifestation of cerebral metastases in a 27-year-old man with non-small cell lung cancer
- 71 Downloads
Brain metastases (BM) occur in 20–40% of patients with non-small cell lung cancer (NSCLC) at some point during the disease course . NSCLC is heterogeneous in terms of its histological subtypes and distinct driving oncogenes , which may affect the development of BM. Adenocarcinoma, identified through histology, has been reported to be associated with BM from NSCLC. Patients with BM from NSCLC often present with headaches, nausea and vomiting, seizures, and meningeal irritation. However, patients with BM from NSCLC who only present with seizures without any evidence of lung cancer are very rare. In this report, we describe a 27-year-old man with BM from NSCLC whose only presenting symptom was seizure.
A 27-year-old man presented to the emergency department during Chinese spring festival with a history of seizures that had been occurring for the previous 5 days. The seizures were described by the paramedics as well as by bystanders as a Jacksonian seizure affecting the...
This work was supported by grants from the National Natural Science Foundation of China (No. 81301119), the Beijing Municipal Administration of Hospitals’ Youth Programme (No. QML20160504), the China Association Against Epilepsy-UCB Research Fund (No. CAAE-UCB2016008), and the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (No. 2013BAI09B03).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Mujoomdar A, Austin JH, Malhotra R, Powell CA, Pearson GD, Shiau MC, Raftopoulos H (2007) Clinical predictors of metastatic disease to the brain from non-small cell lung carcinoma: primary tumor size, cell type, and lymph node metastases. Radiology 242(3):882–888. https://doi.org/10.1148/radiol.2423051707 CrossRefPubMedGoogle Scholar