Antecedent diffuse cerebellar lesions on diffusion-weighted MRI in nonalcoholic Wernicke’s encephalopathy
- 63 Downloads
Wernicke’s encephalopathy is an acute neurologic disorder caused by thiamine (vitamin B1) deficiency. The cause of thiamine deficiency is mainly chronic alcoholism. A variety of other conditions such as malnutrition, sepsis, malignancy, chemotherapy, and hyperemesis gravidarum can also lead to Wernicke’s encephalopathy. In patients with this disorder, magnetic resonance imaging (MRI) is the useful test to support the diagnosis of Wernicke’s encephalopathy, with a sensitivity and specificity of 53 and 93%, respectively . MRI typically shows altered signal intensity in the medial thalami, mammillary bodies, tectal plate, and periaqueductal area because these periventricular regions are possibly more sensitive to the oxidative and glucose metabolisms associated with thiamine. Wernicke’s encephalopathy is typically characterized by ocular signs, ataxia, and altered mental state/memory impairment. However, this clinical triad is present in only approximately 30% of...
Conflict of interest
The authors declare that they have no conflict of interest.
TS and HN examined and wrote the manuscript. HT and FK helped to draft the manuscript and performed the analyses. All authors read and approved the final manuscript.