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Rasagiline for dysexecutive symptoms during wearing-off in Parkinson’s disease: a pilot study

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Abstract

Wearing-off refers to the predictable worsening of motor and sometimes non-motor symptoms of Parkinson’s disease occurring at the end of levodopa dose that improves with the next drug dose. Here, we investigated the efficacy of rasagiline on executive functions at the end of levodopa dose in patients displaying symptoms of wearing-off. Rasagiline was well-tolerated and produced a significant improvement at the Frontal Assessment Battery, together with improvement of motor symptoms at the end of levodopa dose. These results suggest that treatment of motor symptoms of wearing-off with rasagiline may be accompanied by improvement of executive functions, and further support the need for optimizing dopamine replacement therapy in fluctuating Parkinson’s disease patients.

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Funding

Supported by a research grant from Lundbeck to FEP

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Authors and Affiliations

  1. Dipartimento di Neuroscience, Salute Mentale e Organi di Senso, “Sapienza” Università di Roma, Via di Grottarossa, 1035, 00189, Rome, Italy

    Domiziana Rinaldi, Michela Sforza, Stefania Tagliente & Francesco E. Pontieri

  2. Museo Storico della Fisica e Centro Studi e Ricerche “Enrico Fermi”, Piazza del Viminale, 1, 00184, Rome, Italy

    Francesca Assogna

  3. IRCCS “Fondazione Santa Lucia”, Via Ardeatina, 306, 00179, Rome, Italy

    Francesca Assogna & Francesco E. Pontieri

Authors
  1. Domiziana Rinaldi
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  2. Francesca Assogna
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  3. Michela Sforza
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  4. Stefania Tagliente
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  5. Francesco E. Pontieri
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Corresponding author

Correspondence to Francesco E. Pontieri.

Ethics declarations

This pilot study was approved by the local Ethical Committee, and each subject signed informed consent before enrollment.

Conflict of interest

FEP received honoraria for speaking at symposia from Abbvie and Zambon. The other authors have no conflict of interest to declare.

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Rinaldi, D., Assogna, F., Sforza, M. et al. Rasagiline for dysexecutive symptoms during wearing-off in Parkinson’s disease: a pilot study. Neurol Sci 39, 141–143 (2018). https://doi.org/10.1007/s10072-017-3123-2

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  • DOI: https://doi.org/10.1007/s10072-017-3123-2

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