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Does the radiologically isolated syndrome exist? A dual-task cost pilot study

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Abstract

Simultaneous performance of motor and cognitive tasks may compete for common brain network resources in aging or patients with some neurological diseases, suggesting the occurrence of a cognitive-motor interference. While this phenomenon has been well described for multiple sclerosis (MS) patients, it never has been tested on asymptomatic subject with magnetic resonance imaging (MRI) findings suggestive of demyelinating disease (i.e., radiologically isolated syndrome: RIS). In this pilot study, 10 RIS subjects and 10 sex/age-matched healthy controls were tested by means of static posturography under eyes opened (single-task trial) and while performing two different cognitive tasks (semantic modified word list generation for first dual-task trial and phonemic semantic modified word list generation for second dual-task trial), to estimate the dual-task cost (DTC) of standing balance. In our sample, under cognitive interference (without any substantial differences between semantic and phonemic modified word list generation), the RIS group showed significance differences in CoP (center of pressure) total sway area, ellipse eccentricity, CoP sway path length, CoP median sway velocity along the AP (anteroposterior) axis and along the ML (mediolateral) axis, reflecting a higher negative DTC respect to healthy subjects (which have simply shown a statistical trend, failing to reach a significance, in some trials). The phenomenon of cognitive-motor interference might be unmasked by a dual-task posturography in RIS subjects, too. We hypothesize that this approach could be useful to early reveal the presence of a demyelinating disease and to reach a MS diagnosis in subjects otherwise classified as RIS.

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Author notes

  1. Dattola Vincenzo and Logiudice Anna Lisa have contributed equally to this study

Authors and Affiliations

  1. IRCCS Centro Neurolesi “Bonino-Pulejo”, Via P.le Palermo S.S. 113 - CAP, 98124, Messina, Italy

    Vincenzo Dattola, Anna Lisa Logiudice, Lilla Bonanno, Demetrio Milardi, Giangaetano D’Aleo, Silvia Marino, Rocco Salvatore Calabrò & Margherita Russo

  2. Department of Human Pathology, University Hospital of Messina, Via Consolare Valeria, Messina, Italy

    Fausto Famà

  3. Department of Biomedical, Dental Sciences and Morphological and Functional Images, University Hospital of Messina, Via Consolare Valeria, Messina, Italy

    Demetrio Milardi

  4. Department of Clinical and Experimental Medicine, University Hospital of Messina, Via Consolare Valeria, Messina, Italy

    Gaetana Chillemi

Authors
  1. Vincenzo Dattola
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  2. Anna Lisa Logiudice
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Correspondence to Vincenzo Dattola.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Dattola, V., Logiudice, A.L., Bonanno, L. et al. Does the radiologically isolated syndrome exist? A dual-task cost pilot study. Neurol Sci 38, 2007–2013 (2017). https://doi.org/10.1007/s10072-017-3094-3

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  • DOI: https://doi.org/10.1007/s10072-017-3094-3

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