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Validity, reliability, and sensitivity to change of the myasthenia gravis activities of daily living profile in a sample of Italian myasthenic patients

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Abstract

The purpose of this study is to report on the validity, reliability, and sensitivity of the myasthenia gravis activities of daily living profile (MG-ADL) in a sample of Italian patients. Patients with myasthenia gravis (MG) completed a protocol that included the MG-ADL, the WHO Disability Assessment Schedule (WHODAS 2.0), the Besta Neurological Institute rating scale for myasthenia gravis, and the MG-composite. Cronbach’s alpha was used to test reliability, Spearman’s correlation and intra-class correlation coefficient (ICC) to test short-term test-retest, Kruskal-Wallis test to assess differences in MG-ADL between patients with different disease severity, and Wilcoxon signed-rank test to assess sensitivity to change. In total, 58 patients were enrolled: 44 were females, mean MG duration 10.5 ± 10.4 years, mean MG-ADL 3.98 ± 3.07. The MG-ADL showed good internal consistency (alpha = .774), stability (test-retest correlation = .98, ICC = .97). It was superior to the WHODAS 2.0 in differentiating patients with different MG type and severity (P < .001), it showed higher sensitivity to change (P = .001 for improved and P = .007 for worsened patients) and higher correlation with the MG-composite (RHO = .625). Our analysis shows that the Italian version of the MG-ADL is valid, reliable, stable, and sensitive to change.

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Authors and Affiliations

  1. Neurology, Public Health and Disability Unit, Neurological Institute “C. Besta” IRCCS Foundation, Via Celoria 11, 20133, Milan, Italy

    Alberto Raggi & Matilde Leonardi

  2. Department of Neuroimmunology and Neuromuscular Disorders, Neurological Institute “C. Besta” IRCCS Foundation, Milan, Italy

    Carlo Antozzi, Fulvio Baggi, Lorenzo Maggi & Renato Mantegazza

Authors
  1. Alberto Raggi
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  2. Carlo Antozzi
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  3. Fulvio Baggi
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  4. Matilde Leonardi
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  5. Lorenzo Maggi
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  6. Renato Mantegazza
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Corresponding author

Correspondence to Alberto Raggi.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

Funding

This study was supported by Besta Institute Foundation.

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The authors declare that they have no conflict of interest.

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Raggi, A., Antozzi, C., Baggi, F. et al. Validity, reliability, and sensitivity to change of the myasthenia gravis activities of daily living profile in a sample of Italian myasthenic patients. Neurol Sci 38, 1927–1931 (2017). https://doi.org/10.1007/s10072-017-3083-6

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  • DOI: https://doi.org/10.1007/s10072-017-3083-6

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