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Head trauma and Parkinson’s disease: results from an Italian case-control study

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Abstract

We evaluated the possible association between head trauma and Parkinson’s disease (PD). The FRAGAMP (Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson) study is a large Italian multicenter case-control study carried out to evaluate the possible role of environmental and genetic factors in PD. Cases and controls were enrolled from six movement disorders centers located in the Central-Southern Italy. A standardized questionnaire was administered to record demographic, epidemiological, and clinical data. Positive history of head trauma was considered only if the head trauma preceded the onset of PD. All cases and controls underwent a standard neurological examination. Adjusted ORs and 95% CI were estimated using multivariate analysis (logistic regression). Four hundred ninety-two PD patients (292 men and 200 women) and 459 controls (160 men and 299 women) were enrolled in the study. A positive history for head trauma was reported by 106 (21.5%) PD patients and by 62 (13.5%) healthy controls. Multivariate analysis (OR adjusted by age, sex, family history, coffee smoking, and alcohol consumption) showed a significant positive association between PD and head trauma with an adjusted OR of 1.50 (95%CI 1.04–2.17; p value 0.03). In agreement with literature data, our study supports the positive association between head trauma and PD.

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References

  1. de Lau LML, Breteler MMB (2006) Epidemiology of Parkinson’s disease. Lancet Neurol 5:525–535. doi:10.1016/S1474-4422(06)70471-9

    Article  PubMed  Google Scholar 

  2. Crane PK, Gibbons LE, Dams-O’Connor K et al (2016) Association of traumatic brain injury with late-life neurodegenerative conditions and neuropathologic findings. JAMA Neurol. doi:10.1001/jamaneurol.2016.1948

  3. Parkinson J (2002) Essay on the shaking palsy. London: Sherwood, Neely and Jones; 1817. Reprinted in: Neuropsychiatric classics. J Neuropsychiatry Clin Neurosci 14:223-236

  4. Gardner A, Iverson GL, McCrory P (2014) Chronic traumatic encephalopathy in sport: a systematic review. Br J Sports Med 48:84–90. doi:10.1136/bjsports-2013-092646

    Article  PubMed  Google Scholar 

  5. Kenborg L, Rugbjerg K, Lee P-C et al (2015) Head injury and risk for Parkinson disease: results from a Danish case-control study. Neurology 84:1098–1103. doi:10.1212/WNL.0000000000001362

    Article  PubMed  PubMed Central  Google Scholar 

  6. Baldereschi M, Di Carlo A, Rocca WA et al (2000) Parkinson’s disease and parkinsonism in a longitudinal study: two-fold higher incidence in men. ILSA Working Group Italian Longitudinal Study on Aging. Neurology 55:1358–1363

    Article  CAS  PubMed  Google Scholar 

  7. Taylor KM, Saint-Hilaire M-H, Sudarsky L et al (2016) Head injury at early ages is associated with risk of Parkinson’s disease. Parkinsonism Relat Disord 23:57–61. doi:10.1016/j.parkreldis.2015.12.005

    Article  PubMed  Google Scholar 

  8. Tanner CM, Ross GW, Jewell SA et al (2009) Occupation and risk of parkinsonism: a multicenter case-control study. Arch Neurol 66:1106–1113. doi:10.1001/archneurol.2009.195

    Article  PubMed  Google Scholar 

  9. Zorzon M, Capus L, Pellegrino A et al (2002) Familial and environmental risk factors in Parkinson’s disease: a case-control study in north-east Italy. Acta Neurol Scand 105:77–82

    Article  CAS  PubMed  Google Scholar 

  10. Fang F, Chen H, Feldman AL et al (2012) Head injury and Parkinson’s disease: a population-based study. Mov Disord Off J Mov Disord Soc 27:1632–1635. doi:10.1002/mds.25143

    Article  Google Scholar 

  11. Bower JH, Maraganore DM, Peterson BJ et al (2003) Head trauma preceding PD: a case-control study. Neurology 60:1610–1615

    Article  CAS  PubMed  Google Scholar 

  12. Dick FD, De Palma G, Ahmadi A et al (2007) Environmental risk factors for Parkinson’s disease and parkinsonism: the Geoparkinson study. Occup Environ Med 64:666–672. doi:10.1136/oem.2006.027003

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Gardner RC, Burke JF, Nettiksimmons J et al (2015) Traumatic brain injury in later life increases risk for Parkinson disease. Ann Neurol 77:987–995. doi:10.1002/ana.24396

    Article  PubMed  PubMed Central  Google Scholar 

  14. Harris MA, Shen H, Marion SA et al (2013) Head injuries and Parkinson’s disease in a case-control study. Occup Environ Med 70:839–844. doi:10.1136/oemed-2013-101444

    Article  PubMed  Google Scholar 

  15. Rugbjerg K, Ritz B, Korbo L et al (2008) Risk of Parkinson’s disease after hospital contact for head injury: population based case-control study. BMJ 337:a2494

    Article  PubMed  PubMed Central  Google Scholar 

  16. Gao J, Liu R, Zhao E et al (2015) Head injury, potential interaction with genes, and risk for Parkinson’s disease. Parkinsonism Relat Disord 21:292–296. doi:10.1016/j.parkreldis.2014.12.033

    Article  PubMed  PubMed Central  Google Scholar 

  17. Goldman SM, Tanner CM, Oakes D et al (2006) Head injury and Parkinson’s disease risk in twins. Ann Neurol 60:65–72. doi:10.1002/ana.20882

    Article  PubMed  Google Scholar 

  18. Tsai CH, Lo SK, See LC et al (2002) Environmental risk factors of young onset Parkinson’s disease: a case-control study. Clin Neurol Neurosurg 104:328–333

    Article  CAS  PubMed  Google Scholar 

  19. Jafari S, Etminan M, Aminzadeh F, Samii A (2013) Head injury and risk of Parkinson disease: a systematic review and meta-analysis. Mov Disord Off J Mov Disord Soc 28:1222–1229. doi:10.1002/mds.25458

    Article  Google Scholar 

  20. Gelb DJ, Oliver E, Gilman S (1999) Diagnostic criteria for Parkinson disease. Arch Neurol 56:33–39

    Article  CAS  PubMed  Google Scholar 

  21. Nicoletti A, Pugliese P, Nicoletti G et al (2010) The FRAGAMP study: environmental and genetic factors in Parkinson’s disease, methods and clinical features. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol 31:47–52. doi:10.1007/s10072-009-0182-z

    Google Scholar 

  22. Ramlackhansingh AF, Brooks DJ, Greenwood RJ et al (2011) Inflammation after trauma: microglial activation and traumatic brain injury. Ann Neurol 70:374–383. doi:10.1002/ana.22455

    Article  PubMed  Google Scholar 

  23. Loane DJ, Kumar A, Stoica BA et al (2014) Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. J Neuropathol Exp Neurol 73:14–29. doi:10.1097/NEN.0000000000000021

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Schmidt OI, Heyde CE, Ertel W, Stahel PF (2005) Closed head injury—an inflammatory disease? Brain Res Brain Res Rev 48:388–399. doi:10.1016/j.brainresrev.2004.12.028

    Article  PubMed  Google Scholar 

  25. Stoll G, Jander S, Schroeter M (2002) Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system. Adv Exp Med Biol 513:87–113

    CAS  PubMed  Google Scholar 

  26. Mondello S, Buki A, Italiano D, Jeromin A (2013) α-Synuclein in CSF of patients with severe traumatic brain injury. Neurology 80:1662–1668. doi:10.1212/WNL.0b013e3182904d43

    Article  CAS  PubMed  Google Scholar 

  27. Ascherio A, Schwarzschild MA (2016) The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol 15:1257–1272. doi:10.1016/S1474-4422(16)30230-7

    Article  PubMed  Google Scholar 

  28. Arca R, Ricchi V, Murgia D et al (2016) Parkinsonism and dementia are negative prognostic factors for the outcome of subdural hematoma. Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol 37:1299–1303. doi:10.1007/s10072-016-2588-8

    Google Scholar 

  29. Wang H-C, Lin C-C, Lau C-I et al (2014) Risk of accidental injuries amongst Parkinson disease patients. Eur J Neurol 21:907–913. doi:10.1111/ene.12410

    Article  PubMed  Google Scholar 

  30. Sulzer D (2007) Multiple hit hypotheses for dopamine neuron loss in Parkinson’s disease. Trends Neurosci 30:244–250. doi:10.1016/j.tins.2007.03.009

    Article  CAS  PubMed  Google Scholar 

  31. Chaudhuri KR, Martinez-Martin P (2008) Quantitation of non-motor symptoms in Parkinson’s disease. Eur J Neurol 15(Suppl 2):2–7. doi:10.1111/j.1468-1331.2008.02212.x

    Article  PubMed  Google Scholar 

  32. Nicoletti A, Pugliese P, Nicoletti G et al (2010) Voluptuary habits and clinical subtypes of Parkinson’s disease: the FRAGAMP case-control study. Mov Disord Off J Mov Disord Soc 25:2387–2394. doi:10.1002/mds.23297

    Article  Google Scholar 

  33. Nicoletti A, Nicoletti G, Arabia G et al (2011) Reproductive factors and Parkinson’s disease: a multicenter case-control study. Mov Disord Off J Mov Disord Soc 26:2563–2566. doi:10.1002/mds.23951

    Article  Google Scholar 

  34. Nicoletti A, Zappia M, FRAGAMP Study Group (2015) Coffee consumption and risk of levodopa-induced dyskinesia in Parkinson’s disease: the FRAGAMP study. Mov Disord Off J Mov Disord Soc 30:1854–1856. doi:10.1002/mds.26459

    Article  Google Scholar 

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Authors and Affiliations

  1. Dipartimento G.F. Ingrassia, Sezione di Neuroscienze, Università Degli Studi di Catania, Via Santa Sofia 78, 95123, Catania, Italy

    Alessandra Nicoletti, Rosario Vasta, Giovanni Mostile & Mario Zappia

  2. Istituto di Bioimmagini e Fisiologia Molecolare – Consiglio Nazionale delle Ricerche, Catanzaro, Italy

    Giuseppe Nicoletti & Aldo Quattrone

  3. Clinica Neurologica, Università “Magna Græcia” di Catanzaro, Catanzaro, Italy

    Gennarina Arabia & Aldo Quattrone

  4. Dipartimento di Scienze mediche di base, neuroscienze e organi di senso, Università di Bari, Bari, Italy

    Giovanni Iliceto & Paolo Lamberti

  5. Divisione di Neurologia, Ospedale Misericordia, Grosseto, Italy

    Roberto Marconi

  6. Dipartimento di Neuroscienze, Università di Messina, Messina, Italy

    Letterio Morgante

  7. Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, Salerno, Italy

    Paolo Barone

Authors
  1. Alessandra Nicoletti
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  2. Rosario Vasta
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  3. Giovanni Mostile
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  4. Giuseppe Nicoletti
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  5. Gennarina Arabia
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  6. Giovanni Iliceto
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  7. Paolo Lamberti
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  8. Roberto Marconi
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  9. Letterio Morgante
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  10. Paolo Barone
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  11. Aldo Quattrone
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  12. Mario Zappia
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Corresponding author

Correspondence to Mario Zappia.

Ethics declarations

The study was approved by the local ethical committee. Informed consent was obtained from all individual participants included in the study.

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The authors declare that they have no conflict of interest.

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Nicoletti, A., Vasta, R., Mostile, G. et al. Head trauma and Parkinson’s disease: results from an Italian case-control study. Neurol Sci 38, 1835–1839 (2017). https://doi.org/10.1007/s10072-017-3076-5

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  • DOI: https://doi.org/10.1007/s10072-017-3076-5

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