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Glial and neuronal antibodies in patients with idiopathic intracranial hypertension

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Abstract

Headache and visual disturbances are the main presenting symptoms of idiopathic intracranial hypertension (IIH) characterized by increased intracranial pressure (ICP) with an unknown cause. We aimed to investigate the antibodies against optic neuritis-associated glial antigens, aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) and uncharacterized neuronal membrane antigens in IIH patients. Consecutive patients diagnosed according to Friedman revised diagnostic criteria and control subjects were included after their consent. All serum samples were analyzed for antibodies against AQP4 and MOG using cell-based immunofluorescent assays and for uncharacterized neuronal membrane antigens by indirect immunocytochemistry utilizing live neurons. Sera of 34 patients with IIH and 40 control subjects were investigated but none of the patients showed AQP4 and MOG antibodies. However, serum IgG of five IIH patients showed reactivity against membrane antigens of rat hippocampal and cortical neurons. Interestingly, three out of these five patients had nonspecific white matter lesions on MRI, whereas only four of all other patients had these lesions (p = 0.048). AQP4 and MOG antibodies do not seem to have a role in the pathophysiology of IIH. However, association of immunocytochemistry findings with the presence of white matter lesions may suggest that immunological factors contribute to the pathogenesis of IIH in at least some of the patients.

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Acknowledgements

The authors thank the participants for taking part in the study.

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Authors and Affiliations

  1. Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Capa-Fatih, 34104, Istanbul, Turkey

    Güneş Altıokka-Uzun, Betül Baykan, Bedia Samancı, Erdi Şahin, Esme Ekizoğlu & Murat Kürtüncü

  2. Department of Neuroscience, Institute for Experimental Medical Research, Istanbul University, Istanbul, Turkey

    Ece Erdağ & Erdem Tüzün

  3. Tzartos NeuroDiagnostics, Athens, Greece

    John Tzartos, Paraskevi Zisimopoulou, Katerina Karagiorgou & Christos Stergiou

  4. Hellenic Pasteur Institute, Athens, Greece

    John Tzartos

  5. Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Duygu Gezen-Ak & Erdinç Dursun

Authors
  1. Güneş Altıokka-Uzun
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  2. Ece Erdağ
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  3. Betül Baykan
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  4. John Tzartos
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  9. Katerina Karagiorgou
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  13. Murat Kürtüncü
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  14. Erdem Tüzün
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Corresponding author

Correspondence to Güneş Altıokka-Uzun.

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Funding

This study was supported by the Istanbul University Scientific Research Fund (project number: 2016-21774) and by a grant from the Hellenic Neuroimmunology Academy.

Conflict of interest

J. Tzartos has shares in the research and diagnostic center Tzartos NeuroDiagnostics. All others declare no conflict of interest.

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Altıokka-Uzun, G., Erdağ, E., Baykan, B. et al. Glial and neuronal antibodies in patients with idiopathic intracranial hypertension. Neurol Sci 38, 1817–1822 (2017). https://doi.org/10.1007/s10072-017-3066-7

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  • DOI: https://doi.org/10.1007/s10072-017-3066-7

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