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Continuous quantitative monitoring of physical activity in Parkinson’s disease patients by using wearable devices: a case-control study

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Abstract

The objective of this study was to explore the feasibility of using wearable devices to quantitatively measure the daily activity in patients with Parkinson’s disease (PD) and to monitor medication-induced motor fluctuations. In this case-controlled study, we used monitored daily movement function in 21 patients with Parkinson’s disease and 20 healthy volunteers. We analyzed the exercise types and sleep duration in the two groups and evaluated the correlation between daily movement function and age, gender, education, disease duration, Hohn-Yahr stage, UPDRS-II score, UPDRS-III score, and levodopa dose. We also determined the amount of exercise performed by PD patients at 1 h after taking levodopa and at 1 h before the next dose. The type of activity, average speed, and sleep duration in patients were significantly lower in PD patients than in healthy controls (P < 0.05). One hour after taking levodopa, patients were significantly more active than 1 h before the next dose (P < 0.05).Correlation analysis showed that age, gender, education, disease duration, Hohn-Yahr stage, UPDRS-II and UPDRS-III scores, and dosage of levodopa do not correlate with the daily movement function (P > 0.05) in patients with Parkinson’s disease. In the control group, age and education were associated with daily movement function (P < 0.05), while gender was unrelated (P > 0.05). Continuous monitoring of daily activity may be useful to reveal medication-induced motor fluctuations in Parkinson’s disease. The daily movement function may depend on age and education, but not on other parameters.

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Acknowledgements

This work was supported by the Fujian Provincial Health and Family Planning Commission Youth Research Project (2015-1-32), Fujian Provincial Science and Technology Guiding Project (2017Y0041), National Natural Science Foundation of China (81271414), and Key Clinical Specialty Discipline Construction Program of Fujian and Nation, P.R.C.

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Authors and Affiliations

  1. Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian, 350001, China

    Guoen Cai & Qinyong Ye

  2. Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, China

    Yujie Huang

  3. Longyan First Hospital affiliated to Fujian Medical University, Longyan, Fujian, 364000, China

    Shan Luo

  4. Quanzhou Institute of Equipment Manufacturing, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Quanzhou, Fujian, 362200, China

    Zhirong Lin & Houde Dai

Authors
  1. Guoen Cai
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  2. Yujie Huang
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  3. Shan Luo
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  4. Zhirong Lin
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  5. Houde Dai
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  6. Qinyong Ye
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Correspondence to Qinyong Ye.

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The authors declare that they have no conflict of interest regarding the publication of this paper.

Ethics statement

Study participants voluntarily agreed to participate in the study and provided written informed consent prior to enrollment. The study was approved by the Ethics Committee of Union Hospital Affiliated to Fujian Medical University. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Guoen Cai and Yujie Huang are co-first authors.

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Cai, G., Huang, Y., Luo, S. et al. Continuous quantitative monitoring of physical activity in Parkinson’s disease patients by using wearable devices: a case-control study. Neurol Sci 38, 1657–1663 (2017). https://doi.org/10.1007/s10072-017-3050-2

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  • DOI: https://doi.org/10.1007/s10072-017-3050-2

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