Neurological Sciences

, Volume 38, Issue 10, pp 1873–1875 | Cite as

Extra central nervous system metastases from glioblastoma: a new possible trigger event?

  • G. Simonetti
  • A. Silvani
  • L. Fariselli
  • A. F. Hottinger
  • G. A. Pesce
  • F. Prada
  • P. Gaviani
Brief Communication


Extra-cranial metastases of glioblastoma (GBM) represent a rare event, and the biological-genetic mechanisms involved in the pathogenesis have not yet been determined. We report the case of a young patient with multiple visceral and osseous metastases occurred after 4 years after first diagnosis of GBM. The strangeness as well as the rarity of this event does not allow to identify an effective treatment for GBM metastases, making the management of this ominous tumor an even greater challenge.


Glioblastoma Extra-cranial metastases Metastatic tumor Bevacizumab 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Italia S.r.l. 2017

Authors and Affiliations

  1. 1.Neuro Oncology UnitFondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly
  2. 2.Neurosurgery Department, Radiotherapy UnitFondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly
  3. 3.Department of Clinical NeurosciencesCentre Hospitalier Universitaire VaudoisLausanneSwitzerland
  4. 4.Department of Radiation OncologyOncology Institute of Southern SwitzerlandBellinzonaSwitzerland
  5. 5.Department of Radiation OncologyOncology Institute of Southern SwitzerlandLuganoSwitzerland
  6. 6.Department of NeurosurgeryFondazione IRCCS Istituto Neurologico Carlo BestaMilanItaly

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