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Quality of sleep in patients receiving androgen deprivation therapy for prostate cancer

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Abstract

Androgen deprivation is a therapeutic option for patients with prostate cancer (PC). However, it has negative effects on sleep quality and psychological condition. Here, we evaluated the appearance of sleep disturbances in patients on androgen deprivation therapy (ADT). We administered Pittsburgh Sleep Quality Index (PSQI), Beck Depression Inventory (BDI), Epworth Sleepiness Scale (ESS), and Fatigue Severity Scale (FSS) to consecutive prostate cancer patients who had undergone radical prostatectomy and are presently either under adjuvant ADT or followed in an unmedicated program (non-ADT). The results of the tests in ADT and non-ADT groups in addition to the demographic data and the features of the malignancy were statistically compared. Of the 106 patients enrolled, 48 (45.3%) were receiving adjuvant ADT and 58 (54.7%) were not. Age, disease duration, and education levels showed no difference between the two groups. Compared with the non-ADT group, the patients receiving ADT showed higher levels of depression, worse quality of sleep, and more severe fatigue (p < 0.001, for each). There was no significant difference among the two groups regarding excessive daytime sleepiness (p = 0.856). The mean PSQI scores showed a positive correlation with BDI and FSS scores (r = 0.710, p < 0.001; r = 0.528, p < 0.001, respectively). Additionally, ADT was strongly associated with PSQI and FSS scores at multivariate analysis (p = 0.037, p = 0.043, respectively). We conclude that PC patients receiving ADT are likely to be fatigued, more depressed, and had poorer sleep quality. Our study showed that receiving ADT therapy is strongly associated with poor sleep quality and fatigue.

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Authors and Affiliations

  1. Department of Neurology, Izmir Bozyaka Education and Research Hospital, Saim Cikrikci Cad. No:59, Bozyaka/Karabaglar, 35170, Izmir, Turkey

    Asli Koskderelioglu, Muhtesem Gedizlioglu & Nilden Kahyaoglu

  2. Department of Urology, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey

    Yasin Ceylan & Bulent Gunlusoy

Authors
  1. Asli Koskderelioglu
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  2. Muhtesem Gedizlioglu
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  3. Yasin Ceylan
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  4. Bulent Gunlusoy
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  5. Nilden Kahyaoglu
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Correspondence to Asli Koskderelioglu.

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The study protocol was approved by the local ethics committee, and all of the subjects gave written informed consent to participate.

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There were no funding sources for the study.

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The authors declare that they have no conflict of interest.

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Koskderelioglu, A., Gedizlioglu, M., Ceylan, Y. et al. Quality of sleep in patients receiving androgen deprivation therapy for prostate cancer. Neurol Sci 38, 1445–1451 (2017). https://doi.org/10.1007/s10072-017-2989-3

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  • DOI: https://doi.org/10.1007/s10072-017-2989-3

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