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Dynamics of change in self-reported disability among persons with Parkinson’s disease after 2 years of follow-up

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Abstract

Symptoms of Parkinson’s disease (PD) progress over time causing significant disability. Yet, change in disability over shorter time periods has not been entirely understood. The purpose of this study was to assess the Self-Assessment Disability Scale (SADS) in persons with Parkinson’s disease (PD) after 2 years of follow-up and compare it with the score observed at baseline. Additionally, we aimed at evaluating association of motor and non-motor PD features at baseline with a higher disability after 2 years of follow-up. A total of 120 consecutive persons with PD, who denied falling in the past 6 months, were initially recruited. After 2 years of follow-up, 88 (73.3%) persons with PD were evaluated for SADS. The total disability (SADS) score did not change after follow-up (p = 0.529). We observed increase in difficulty at “Getting out of bed” (p = 0.006), “Getting up out of armchair” (p = 0.013), “Walking about house/flat” (p = 0.003), “Walking outside” (p = 0.010), and “Traveling by public transport” (p = 0.014). After adjusting for several potential confounding factors, falls in the past year (β = 8.32, 95% confidence interval (CI) 1.04–15.59) and higher Unified Parkinson’s Disease Rating Scale part 3 at baseline (β = 0.26, 95%CI 0.01–0.51) remained associated with higher PD-related disability. This finding suggests that accumulation of overall PD-related disability tends to occur over a longer time span. Further studies are needed to gradually assess long-term evolution of disability in PD.

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Acknowledgement

This investigation was supported by the Ministry of Education and Science of the Republic of Serbia (Grants No 175087 and 175090).

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Authors and Affiliations

  1. Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Visegradska 26A, Belgrade, 11000, Serbia

    Tatjana Gazibara, Darija Kisic-Tepavcevic & Tatjana Pekmezovic

  2. Clinic of Neurology, Faculty of Medicine, Clinical Centre of Serbia, University of Belgrade, Belgrade, Serbia

    Marina Svetel, Aleksandra Tomic, Iva Stankovic & Vladimir Kostic

Authors
  1. Tatjana Gazibara
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  2. Darija Kisic-Tepavcevic
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  3. Marina Svetel
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  4. Aleksandra Tomic
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  5. Iva Stankovic
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  6. Vladimir Kostic
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  7. Tatjana Pekmezovic
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Corresponding author

Correspondence to Tatjana Pekmezovic.

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The study was approved by the Ethical Committee of the Faculty of Medicine of the University of Belgrade.

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The authors declare that they have no conflict of interest.

Research involving human participants

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Gazibara, T., Kisic-Tepavcevic, D., Svetel, M. et al. Dynamics of change in self-reported disability among persons with Parkinson’s disease after 2 years of follow-up. Neurol Sci 38, 1415–1421 (2017). https://doi.org/10.1007/s10072-017-2967-9

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  • DOI: https://doi.org/10.1007/s10072-017-2967-9

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