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Neurological Sciences

, Volume 38, Issue 6, pp 1093–1099 | Cite as

Myxovirus resistance protein A (MxA) polymorphism is associated with IFNβ response in Iranian multiple sclerosis patients

  • Arezou Sayad
  • Soudeh Ghafouri-Fard
  • Mir Davood Omrani
  • Rezvan Noroozi
  • Mohammad TaheriEmail author
Original Article

Abstract

Multiple sclerosis (MS) is a heterogeneous immune-related demyelinating disorder of central nervous system with several genetic and environmental factors contributing in its pathogenesis or patients’ response to therapies. Myxovirus resistance protein A (MxA) is among the genes which are induced by IFNβ and are involved in the MS pathogenesis and/or response to IFNβ. In the present case-control study, we evaluated the association between three SNPs at nt −123 (A or C, rs17000900), nt −88 (G or T, rs2071430), and nt +20 (A or C, rs464138) and MS risk as well as treatment response in a population of Iranian MS patients including 146 IFNβ responders and 85 non-responders as well as 180 healthy controls. The AGA (−123, −88, +20) haplotype was more frequent in controls compared with MS cases (P = 0.038, OR (95% CI) = 1.77 (1.03–3.02)). Of particular note, the frequency of rs464138 AA genotype was significantly higher in responders compared with non-responders. However, the allele and genotype frequencies of other SNPs were not significantly different among patient subtypes or between patients and controls. Besides, we have demonstrated that CGC, ATA, and AGA (−123, −88, +20) haplotypes were significantly associated with IFNβ response in MS patients. As SNPs on MxA promoter region might participate in MS patients’ response to IFNβ, prior patients genotyping may increase the rate of responsiveness and help in individualized selection of treatment options.

Keywords

Multiple sclerosis MxA Polymorphism 

Notes

Acknowledgements

This research was supported by department of medical genetics of Shahid Beheshti University of medical science of Iran. Grant number: 11186.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia 2017

Authors and Affiliations

  • Arezou Sayad
    • 1
  • Soudeh Ghafouri-Fard
    • 1
  • Mir Davood Omrani
    • 1
    • 2
  • Rezvan Noroozi
    • 1
  • Mohammad Taheri
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Medical Genetics, School of MedicineShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Urogenital Stem Cell Research CenterShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Department of Medical Genetics, Faculty of MedicineShahid Beheshti University of Medical SciencesTehranIran

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