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Genetic association study between RIT2 and Parkinson’s disease in a Han Chinese population

Neurological Sciences volume 38, pages 343–347 (2017)Cite this article

Abstract

Recent several meta-analyses and certain case–control studies suggested that the Ras-like without CAAX 2 (RIT2) rs12456492 increased the risk of Parkinson’s disease (PD) in Asian and Caucasian populations. However, as so far, the association between RIT2 rs12456492 and PD is still controversial. We investigated genetic association of RIT2 rs12456492 with PD susceptibility in a Han Chinese population of 1747 ethnic Han Chinese subjects comprising 884 PD patients and 863 healthy controls. The minor allele frequency (MAF) of G at the RIT2 rs12456492 was not significantly different between the cases and the controls. Furthermore, no significant differences were observed in genotype distribution between PD patients and healthy controls for the RIT2 rs12456492, even after being stratified by age at onset and gender. In addition, we found that no significant differences were detected in the clinical manifestations for gender, age at onset, and onset symptoms between PD patients with AG + GG genotypes and those with AA genotypes. Our study from the mainland China demonstrates that RIT2 rs12456492 do not increase the risk of developing PD. Therefore, more replication studies in additional Chinese population and other cohorts are warranted to further clarify the role of RIT2 rs12456492 in PD susceptibility.

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Acknowledgements

The study was supported by West China Hospital of Sichuan University, and Science and Technology Department of Sichuan Province (Number 2013SZ0003). We gratefully acknowledge Prof. Dong Zhou, Li He, Guanggu Yuan, and Yingru Gou. We would also like to thank Xueli Chang, Xueye Mao, Dongmei Zhao, Jinhong Zhang, and Qiao Liao for their help.

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    Affiliations

    1. Department of Neurology, West China Hospital, Sichuan University, 610041, Sichuan, People’s Republic of China

      Jun-Ying Li, Jin-hong Zhang, Nan-Nan Li, Ling Wang, Zhong-Jiao Lu, Lan Cheng, Xiao-Yi Sun & Rong Peng

    2. Department of Internal Medicine, Wangjiang Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China

      Jin-hong Zhang

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    1. Jun-Ying Li
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    2. Jin-hong Zhang
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    3. Nan-Nan Li
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    4. Ling Wang
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    6. Lan Cheng
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    7. Xiao-Yi Sun
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    8. Rong Peng
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    Correspondence to Rong Peng.

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    Jun-Ying Li and Jin-hong Zhang contributed equally to this study.

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    Li, JY., Zhang, Jh., Li, NN. et al. Genetic association study between RIT2 and Parkinson’s disease in a Han Chinese population. Neurol Sci 38, 343–347 (2017). https://doi.org/10.1007/s10072-016-2784-6

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    • DOI: https://doi.org/10.1007/s10072-016-2784-6

    Keywords

    • Parkinson’s disease
    • RIT2
    • rs12456492