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Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis

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Abstract

The activity of angiotensin-converting enzyme (ACE) has been increased in the blood and cerebrospinal fluid of multiple sclerosis (MS) patients. In addition, there has been suppression of disease development in experimental autoimmune encephalomyelitis after blockade of ACE. These findings suggest that ACE may play a role in the MS pathogenesis. Since the previous studies investigating the association between the insertion/deletion (I/D) polymorphism in intron 16 of the ACE gene and MS reported contradictory results, we performed a meta-analysis of four studies conducted in European populations of Slavic origin (1062 patients and 1067 controls) using the Comprehensive Meta-analysis 3.0 software. The results demonstrated that the ACE I/D polymorphism had no statistically significant association with an increased MS risk (all p ≥ 0.05) under all genetic comparison models: (1) allelic (D vs. I), (2) recessive (DD vs. ID + II), (3) dominant (DD + ID vs. II), and (4) additive (DD vs. ID vs. II). This meta-analysis indicates that the ACE I/D polymorphism is not associated with susceptibility to MS in Europeans of Slavic origin. Further studies with larger sample sizes from genetically different populations are warranted.

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Abbreviations

ACE:

Angiotensin-converting enzyme

Ang I:

Angiotensin I

Ang II:

Angiotensin II

CI:

95 % confidence intervals

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

EAE:

Experimental autoimmune encephalomyelitis

MS:

Multiple sclerosis

OR:

Odds ratio

RAS:

Renin-angiotensin system

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Acknowledgments

This work was supported by the University of Rijeka, Republic of Croatia (grant number 13.06.1.1.10).

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Authors and Affiliations

  1. Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Braće Branchetta 20, 51000, Rijeka, Croatia

    Smiljana Ristić, Nada Starčević Čizmarević & Miljenko Kapović

  2. Postgraduate Studies, School of Medicine, University of Rijeka, Rijeka, Croatia

    Juraj Sepčić

  3. Clinical Institute of Medical Genetics, University Medical Centre, Ljubljana, Slovenia

    Borut Peterlin

Authors
  1. Smiljana Ristić
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  2. Nada Starčević Čizmarević
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  3. Juraj Sepčić
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  4. Miljenko Kapović
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  5. Borut Peterlin
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Correspondence to Smiljana Ristić.

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Ristić, S., Čizmarević, N.S., Sepčić, J. et al. Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis. Neurol Sci 37, 1955–1959 (2016). https://doi.org/10.1007/s10072-016-2698-3

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  • DOI: https://doi.org/10.1007/s10072-016-2698-3

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