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Neurological Sciences

, Volume 37, Issue 10, pp 1663–1669 | Cite as

Evaluation of carotid intima-media thickness in children with migraine: a marker of subclinical atherosclerosis

  • Hatice Gamze PoyrazogluEmail author
  • Umit Erkan Vurdem
  • Alev Arslan
  • Salih Uytun
Original Article

Abstract

Migraine is a commonly seen neurovascular disorder during childhood. Inflammation induced by the activation of cytokines and neuropeptides is implied in its pathophysiology. There is an association between inflammation and atherosclerosis in patients with migraine. In addition, there is a strong correlation between early atherosclerotic wall lesions and carotid intima–media thickness (CIMT). The study population consisted of 57 migraine patients aged 5–17 years, as well as 47 healthy children who served as the control group. Those migraine patients who were not receiving any medications at the interictal period were compared to healthy controls in terms of their measured lipid levels, thyroid function, vitamin B12 levels, serum iron levels, iron binding capacity, complete blood count, C-reactive protein (CRP) levels, and carotid intima-media thickness (CIMT) scores, which may comprise risk factors for atherosclerosis. When children in the migraine and control groups were compared in terms of those risk factors that are known to be related to vascular changes, no significant differences were found. However, a significant difference was detected in CIMT values (P < 0.05). Atherosclerosis commences in childhood, and there is a long period of time before the onset of ischemic symptoms occurs. In children with migraine, an evaluation of CIMT can be used as a non-invasive imaging modality to detect atherosclerosis, which develops in the context of chronic inflammation. In this way, measures to reduce morbidity and mortality, which may result from cardiovascular diseases, can be implemented.

Keywords

Migraine Subclinical atherosclerosis Carotid intima-media thickness Child 

Notes

Acknowledgments

This article is not supported by any foundation.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Italia 2016

Authors and Affiliations

  • Hatice Gamze Poyrazoglu
    • 1
    Email author
  • Umit Erkan Vurdem
    • 2
  • Alev Arslan
    • 3
  • Salih Uytun
    • 4
  1. 1.Division of Pediatric Neurology, Department of PediatricsMedical School of Firat UniversityElazıgTurkey
  2. 2.Department of RadiologyKayseri Training and Research HospitalKayseriTurkey
  3. 3.Division of Pediatric Cardiology, Medical Faculty Adana Medical and Research CenterBaskent UniversityAdanaTurkey
  4. 4.Department of PediatricsKayseri Training and Research HospitalKayseriTurkey

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