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Evaluation of carotid intima-media thickness in children with migraine: a marker of subclinical atherosclerosis

Neurological Sciences volume 37, pages 1663–1669 (2016)Cite this article

Abstract

Migraine is a commonly seen neurovascular disorder during childhood. Inflammation induced by the activation of cytokines and neuropeptides is implied in its pathophysiology. There is an association between inflammation and atherosclerosis in patients with migraine. In addition, there is a strong correlation between early atherosclerotic wall lesions and carotid intima–media thickness (CIMT). The study population consisted of 57 migraine patients aged 5–17 years, as well as 47 healthy children who served as the control group. Those migraine patients who were not receiving any medications at the interictal period were compared to healthy controls in terms of their measured lipid levels, thyroid function, vitamin B12 levels, serum iron levels, iron binding capacity, complete blood count, C-reactive protein (CRP) levels, and carotid intima-media thickness (CIMT) scores, which may comprise risk factors for atherosclerosis. When children in the migraine and control groups were compared in terms of those risk factors that are known to be related to vascular changes, no significant differences were found. However, a significant difference was detected in CIMT values (P < 0.05). Atherosclerosis commences in childhood, and there is a long period of time before the onset of ischemic symptoms occurs. In children with migraine, an evaluation of CIMT can be used as a non-invasive imaging modality to detect atherosclerosis, which develops in the context of chronic inflammation. In this way, measures to reduce morbidity and mortality, which may result from cardiovascular diseases, can be implemented.

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References

  1. Li H, Yu Y (2013) Association between ischemic stroke and migraine in elderly Chinese: a case-control study. BMC Geriatr 13:126. doi:10.1186/1471-2318-13-126

    Article  PubMed  PubMed Central  Google Scholar 

  2. Hamed SA (2009) The vascular risk associations with migraine: relation to migraine susceptibility and progression. Atherosclerosis 205:15–22

    CAS  Article  PubMed  Google Scholar 

  3. Schürks M, Rist PM, Bigal ME et al (2009) Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 27(339):b3914. doi:10.1136/bmj.b3914

    Article  Google Scholar 

  4. Cirillo M, Stellato D, Lombardi C, De Santo NG, Covelli V (1999) Headache and cardiovascular risk factors: positive association with hypertension. Headache 39(6):409–416

    CAS  Article  PubMed  Google Scholar 

  5. Hamed SA, Hamed EA, Ezz Eldin AM, Mahmoud NM (2010) Vascular risk factors, endothelial function, and carotid thickness in patients with migraine: relationship to atherosclerosis. J Stroke Cerebrovasc Dis 19(2):92–103

    Article  PubMed  Google Scholar 

  6. Jadhav UM, Kadam NN (2001) Carotid intima-media thickness as an independent predictor of coronary artery disease. Indian Heart J 53(4):458–462

    CAS  PubMed  Google Scholar 

  7. Simons PC, Algra A, Bots ML, Grobbee DE, van der Graaf Y (1999) Common carotid intima-media thickness and arterial stiffness: indicators of cardiovascular risk in high-risk patients. The SMART Study (Second Manifestations of Arterial disease). Circulation 100(9):951–957

    CAS  Article  PubMed  Google Scholar 

  8. Mackinnon AD, Jerrard-Dunne P, Sitzer M et al (2004) Rates and determinants of site-specific progression of carotid artery intima-media thickness: the carotid atherosclerosis progression study. Stroke 35(9):2150–2154

    Article  PubMed  Google Scholar 

  9. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Hernandez Hernandez R, Jaff M, Kownator S, Naqvi T, Prati P, Rundek T, Sitzer M, Schminke U, Tardif JC, Taylor A, Vicaut E, Woo KS (2012) Mannheim carotid intima-media thickness and plaque consensus (2004–2006–2011): an update on behalf of the advisory board of the 3rd and 4th watching the risk symposium 13th and 15th European stroke conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 34(4): 290–296

  10. Stam AH, Weller CM, Janssens AC et al (2013) Migraine is not associated with enhanced atherosclerosis. Cephalalgia 33(4):228–235. doi:10.1177/0333102412466966

    Article  PubMed  Google Scholar 

  11. Schwaiger J, Kiechl S, Stockner H et al (2008) Burden of atherosclerosis and risk of venous thromboembolism in patients with migraine. J Neurol 71(12):937–943

    CAS  Article  Google Scholar 

  12. Welch KM, Brandes AW, Salerno L, Brandes JL (2006) C-reactive protein may be increased in migraine patients who present with complex clinical features. Headache 46(2):197–199

    CAS  Article  PubMed  Google Scholar 

  13. Bolay H, Reuter U, Dunn AK et al (2002) Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med 8(2):136–142

    CAS  Article  PubMed  Google Scholar 

  14. Munno I, Marinaro M, Bassi A et al (2001) Immunological aspects in migraine: increased of IL-10 plasma levels during attack. Headache 41(8):764–767

    CAS  Article  PubMed  Google Scholar 

  15. Pezzini A, Del Zotto E, Giossi A et al (2010) The migraine ischemic stroke relation in young adults. Stroke Res Treat 2011:304921. doi:10.4061/2011/304921

    PubMed  PubMed Central  Google Scholar 

  16. Besir FH, Koçer A, Dikici S, Yazgan S, Ozdem Ş (2013) The evaluation of atherosclerosis in migraine patients. Pain Pract 13(1):41–45. doi:10.1111/j.1533-2500.2012.00551.x

    Article  PubMed  Google Scholar 

  17. Silva FA, Rueda-Clausen CF, Silva SY et al. (2007) Endothelial function in patients with migraine during the interictal period. Headache 47:45–51

    Article  PubMed  Google Scholar 

  18. Guldiken B, Guldiken S, Demir M, et al. (2008) Insulin resistance and high sensitivity C-reactive protein in migraine. Can J Neurol Sci 35:448–451

    Google Scholar 

  19. Gudmundsson LS, Aspelund T, Scher AI et al. (2009) C-reactive protein in migraine sufferers similar to that of non-migraineurs: the Reykjavik Study. Cephalalgia 29:1301–1310

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  20. Rockett FC, Perla Ada S, Perry ID, Chaves ML (2013) Cardiovascular disease risk in women with migraine. J Headache Pain 14(1):75. doi:10.1186/1129-2377-14-75

    Article  PubMed  PubMed Central  Google Scholar 

  21. Fava A, Pirritano D, Consoli D et al. (2014) Chronic migraine in women is associated with insulin resistance: a cross-sectional study. Eur J Neurol 21:267–272

    CAS  Article  PubMed  Google Scholar 

  22. Lippi G, Mattiuzzi C, Cervellin G (2014) C-reactive protein and migraine. Facts or speculations? Clin Chem Lab Med 52(9):1265–1272. doi:10.1515/cclm-2014-0011

    CAS  PubMed  Google Scholar 

  23. Lippi G, Favaloro EJ, Montagnana M, Franchini M (2010) C-reactive protein and venous thromboembolism: causal or casual association? Clin Chem Lab Med 48:1693–1701

    CAS  PubMed  Google Scholar 

  24. Simon A, Gariepy J, Chironi G, Megnien J, Levenson J (2002) Intima media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J Hypertens 20(2):159–169

    CAS  Article  PubMed  Google Scholar 

  25. Nair SB, Malik R, Khattar RS (2012) Carotid intima-media thickness: ultrasound measurement, prognostic value and role in clinical practice. Postgrad Med J 88(1046):694–699

    Article  PubMed  Google Scholar 

  26. Akin MA, Sarici D, Yikilmaz A et al (2013) Aortic intima-media thickness in newborns with congenital hypothyroidism. Horm Res Paediatr. 80:267–272

    CAS  Article  PubMed  Google Scholar 

  27. Kotsis VT, Stabouli SV, Papamichael CM, Zakopoulos NA (2006) Impact of obesity in intima media thickness of carotid arteries. Obesity (Silver Spring) 14(10):1708–1715

    Article  Google Scholar 

  28. Dalla Pozza R, Beyerlein A, Thilmany C et al (2011) The effect of cardiovascular risk factors on the longitudinal evolution of the carotid intima medial thickness in children with type 1 diabetes mellitus. Cardiovasc Diabetol 10:53. doi:10.1186/1475-2840-10-53

    Article  PubMed  PubMed Central  Google Scholar 

  29. Tzourio C, Gagnière B, El Amrani M, Alpérovitch A, Bousser MG (2003) Relationship between migraine, blood pressure and carotid thickness. A population-based study in the elderly. Cephalalgia 23(9):914–920

    CAS  Article  PubMed  Google Scholar 

  30. De Hoon JN, Willigers JM, Troost J, Struijker-Boudier HA, Van Bortel LM (2003) Cranial and peripheral interictal vascular changes in migraine patients. Cephalalgia 23(2):96–104

    CAS  Article  PubMed  Google Scholar 

  31. Iversen HK, Nielsen TH, Olesen J, Tfelt-Hansen P (1990) Arterial responses during migraine headeache. Lancet 336(8719):837–839

    CAS  Article  PubMed  Google Scholar 

  32. Etminan M, Takkouche B, Isorna FC, Samii A (2005) Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ 330(7482):63

    Article  PubMed  PubMed Central  Google Scholar 

  33. Sacco S, Kurth T (2014) Migraine and the risk for stroke and cardiovascular disease. Curr Cardiol Rep 16(9):524

    Article  PubMed  Google Scholar 

  34. Bigal ME, Kurth T, Santanello N et al (2010) Migraine and cardiovascular disease: a population-based study. Neurology 74(8):628–635

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  35. Spector JT, Kahn SR, Jones MR et al (2010) Migraine headache and ischemic stroke risk: an updated meta-analysis. Am J Med 123(7):612–624

    Article  PubMed  PubMed Central  Google Scholar 

  36. Del Zotto E, Pezzini A, Giossi A, Volonghi I, Padovani A (2008) Migraine and ischemic stroke: a debated question. J Cereb Blood Flow Metab 28(8):1399–1421. doi:10.1038/jcbfm.2008.36

    Article  PubMed  Google Scholar 

  37. Welch KMA, Ramadan NM (1995) Mitochondria, magnesium and migraine. J Neurol Sci 134:9–14

    CAS  Article  PubMed  Google Scholar 

  38. DoyonA, Kracht D, Beyazit AK et al. (2013) Carotid artery intima-media thickness and distensibility in children and adolescents: reference values and role of body dimensions. Hypertens 62(3):550–556

    Article  Google Scholar 

  39. Jourdan C, Wühl E, Litwin M et al. (2005) Normative values for intima-media thickness and distensibility of large arteries in healthy adolescents. J Hypertens 23(9):1707–1715

    CAS  Article  PubMed  Google Scholar 

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Acknowledgments

This article is not supported by any foundation.

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Affiliations

  1. Division of Pediatric Neurology, Department of Pediatrics, Medical School of Firat University, 23119, Elazıg, Turkey

    Hatice Gamze Poyrazoglu

  2. Department of Radiology, Kayseri Training and Research Hospital, Kayseri, Turkey

    Umit Erkan Vurdem

  3. Division of Pediatric Cardiology, Medical Faculty Adana Medical and Research Center, Baskent University, Adana, Turkey

    Alev Arslan

  4. Department of Pediatrics, Kayseri Training and Research Hospital, Kayseri, Turkey

    Salih Uytun

Authors
  1. Hatice Gamze Poyrazoglu
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  2. Umit Erkan Vurdem
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  3. Alev Arslan
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  4. Salih Uytun
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Correspondence to Hatice Gamze Poyrazoglu.

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Poyrazoglu, H.G., Vurdem, U.E., Arslan, A. et al. Evaluation of carotid intima-media thickness in children with migraine: a marker of subclinical atherosclerosis. Neurol Sci 37, 1663–1669 (2016). https://doi.org/10.1007/s10072-016-2648-0

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  • DOI: https://doi.org/10.1007/s10072-016-2648-0

Keywords

  • Migraine
  • Subclinical atherosclerosis
  • Carotid intima-media thickness
  • Child