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Elevation of serum heat-shock protein levels in amyotrophic lateral sclerosis

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Abstract

Heat-shock proteins (HSPs) have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study, we aimed to examine whether the serum levels of HSPs (HSP27, HSP70, and HSP90) are altered in patients with ALS. We included 58 patients diagnosed with ALS and 85 control individuals. Serum HSP levels of patients and controls were determined using enzyme-linked immunosorbent assay. The serum levels of HSP70 and HSP90 were significantly higher in patients than in controls. In contrast, serum levels of HSP27 did not differ significantly between the patient and control groups. Moreover, serum levels of HSP70 and HSP90 in patients remained high throughout the duration of the disease. Taken together, our findings suggest that HSPs might have a role in ALS progression throughout the course of the disease. Further studies are needed to clarify the role of HSPs in the pathogenesis of ALS.

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Acknowledgments

This study was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan by a Grant-in-Aid from the Promotion Project of Education, Research, and Medical Care.

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Authors and Affiliations

  1. Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan

    Daigo Miyazaki, Akinori Nakamura, Akiyo Hineno, Chinatsu Kobayashi, Tomomi Kinoshita & Shu-ichi Ikeda

  2. Intractable Disease Care Center, Shinshu University Hospital, Asahi 3-1-1, Matsumoto, 390-8621, Japan

    Daigo Miyazaki & Akinori Nakamura

  3. Division of Neurogenetics, Department of Brain Disease Research, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, 390-8621, Japan

    Kunihiro Yoshida

Authors
  1. Daigo Miyazaki
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  2. Akinori Nakamura
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  3. Akiyo Hineno
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  4. Chinatsu Kobayashi
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  5. Tomomi Kinoshita
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  6. Kunihiro Yoshida
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  7. Shu-ichi Ikeda
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Correspondence to Akinori Nakamura.

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Miyazaki, D., Nakamura, A., Hineno, A. et al. Elevation of serum heat-shock protein levels in amyotrophic lateral sclerosis. Neurol Sci 37, 1277–1281 (2016). https://doi.org/10.1007/s10072-016-2582-1

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  • DOI: https://doi.org/10.1007/s10072-016-2582-1

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