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Glutathione S-transferases variants as risk factors in Alzheimer’s disease

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Abstract

Glutathione S-transferase (GST) was suggested as an important contributor to Alzheimer’s disease (AD). The GSTs polymorphisms have been investigated as candidate genetic risk factors for AD, yet results remained uncertain. Therefore, we performed a meta-analysis to clarify the relationship of GSTs polymorphisms with the occurrence of AD. PubMed, Embase, Cochrane library and Alzgene databases were searched and potential literatures were selected. Pooled analyses and subgroup analyses were conducted, and also publication bias tests and cumulative meta-analysis. This meta-analysis suggested null associations between polymorphisms of GSTM1, GSTT1, GSTM3, GSTP1, GSTO1 and AD risk. GSTs variants may not have an impact on the morbidity of Alzheimer’s disease. Further well designed researches are required to confirm these findings of the current study.

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Acknowledgments

The author thanks Xiang Li for his excellent work in article screening and data extraction.

Conflict of interest

None declared.

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Authors and Affiliations

  1. Department of Pharmacology, University of Tennessee Health Science Center, Room 115, Crowe Building, 874 Union Ave., Memphis, TN, 38163, USA

    Tengfei Wang

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  1. Tengfei Wang
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Correspondence to Tengfei Wang.

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Wang, T. Glutathione S-transferases variants as risk factors in Alzheimer’s disease. Neurol Sci 36, 1785–1792 (2015). https://doi.org/10.1007/s10072-015-2245-7

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  • DOI: https://doi.org/10.1007/s10072-015-2245-7

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