Neurological Sciences

, Volume 36, Issue 2, pp 203–208 | Cite as

Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine

  • Halina Duarte
  • Antonio L. Teixeira
  • Natália P. Rocha
  • Renan B. DominguesEmail author
Original Article


Inflammatory mediators have been studied in migraine pathophysiology; however, their role is not yet well established. The aim of the present study was to investigate interictal chemokine levels and its association with clinical parameters and psychiatric comorbidities in migraine patients compared with controls. This was a cross-sectional study including age and gender matched migraine patients and controls. Beck Depression and Anxiety Inventories, Headache Impact Test, and Allodynia Symptom Checklist were recorded. Chemokines were measured by ELISA. Forty-nine migraine patients and forty-nine controls without headache were included. CXCL8/IL-8 and CCL3/MIP-1α levels were significantly higher among patients with migraine (P = 0.039 and 0.02, respectively) even after controlling for anxiety and depression scores. Chemokine levels were not correlated with migraine impact as well as allodynia scores. CXCL8/IL-8 and CCL3/MIP-1 α levels were raised in migraine, independently of psychiatric comorbidities, migraine impact, and allodynia.


Migraine Chemokines Anxiety Depression Allodynia 



This study was funded by CNPq and Fapemig, Brazil. We gratefully acknowledge the contribution of Cássio B. Lacerda and Tarnara Campostrini in data collection (School of Health Sciences of “Santa Casa de Misericordia de Vitoria”, Brazil).

Conflict of interest



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Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  • Halina Duarte
    • 1
  • Antonio L. Teixeira
    • 1
    • 2
  • Natália P. Rocha
    • 2
  • Renan B. Domingues
    • 1
    • 3
    • 4
    Email author
  1. 1.Neurosciences Postgraduation ProgramFederal University of Minas Gerais (UFMG)Belo HorizonteBrazil
  2. 2.Interdisciplinar Laboratory of Medical Investigation, School of MedicineFederal University of Minas Gerais (UFMG)Belo HorizonteBrazil
  3. 3.CHRULilleFrance
  4. 4.CAPES FoudationMinistry of EducationBrasiliaBrazil

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