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Vitamin D receptor polymorphisms and susceptibility to Parkinson’s disease and Alzheimer’s disease: a meta-analysis

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Abstract

The goal of this study was to examine whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to Parkinson’s disease (PD) and Alzheimer’s disease (AD). A meta-analysis was performed to investigate the association between VDR FokI, BsmI, TaqI, ApaI, rs4334089, or rs11568820 polymorphism and susceptibility to PD or AD. Thirteen studies, including seven on PD and six on AD, were included in this meta-analysis. The meta-analysis revealed an association between the BB + Bb genotype and PD in the Asian population (OR 0.478, 95 % CI 0.259–0.884, p = 0.018). We also observed a significant association between PD and the FokI F allele (OR 1.413, 95 % CI 1.144–1.746, p = 0.001). Meta-analysis of the A allele, the AA vs. Aa + aa, and the AA vs. aa for the ApaI polymorphism revealed significant associations with AD (OR 0.729, 95 % CI 0.0.591–0.900, p = 0.034; OR 0.591, 95 % CI 0.431–0.810, p = 0.001; OR 0.580, 95 % CI 0.361–0.931, p = 0.024, respectively). This meta-analysis demonstrates that the VDR BsmI polymorphism is associated with PD susceptibility in Asians, and the FokI polymorphism is associated with PD. Furthermore, we identified associations between the VDR TaqI and ApaI polymorphisms and AD susceptibility.

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References

  1. Boada M, Antunez C, Lopez-Arrieta J, Caruz A, Moreno-Rey C, Ramirez-Lorca R et al (2012) Estrogen receptor alpha gene variants are associated with Alzheimer’s disease. Neurobiol Aging 33(1):198 e15–198 e24

    Article  Google Scholar 

  2. Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM et al (2013) Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: the PDGene database. PLoS Genet 8(3):e1002548

    Article  Google Scholar 

  3. Fernandes de Abreu DA, Eyles D, Feron F (2009) Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology 34(Suppl 1):S265–S277

    Article  CAS  PubMed  Google Scholar 

  4. Maruotti N, Cantatore FP (2010) Vitamin D and the immune system. J Rheumatol 37(3):491–495

    Article  CAS  PubMed  Google Scholar 

  5. Vinh Quoc Luong K, Thi Hoang Nguyen L (2012) Vitamin D and Parkinson’s disease. J Neurosci Res 90(12):2227–2236

    Article  PubMed  Google Scholar 

  6. Valdivielso JM, Fernandez E (2006) Vitamin D receptor polymorphisms and diseases. Clin Chim Acta 371(1–2):1–12

    Article  CAS  PubMed  Google Scholar 

  7. Miyamoto K, Kesterson RA, Yamamoto H, Taketani Y, Nishiwaki E, Tatsumi S et al (1997) Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol Endocrinol 11(8):1165–1179

    Article  CAS  PubMed  Google Scholar 

  8. Morrison NA, Yeoman R, Kelly PJ, Eisman JA (1992) Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin. Proc Natl Acad Sci USA 89(15):6665–6669

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Arai H, Miyamoto K, Taketani Y, Yamamoto H, Iemori Y, Morita K et al (1997) A vitamin D receptor gene polymorphism in the translation initiation codon: effect on protein activity and relation to bone mineral density in Japanese women. J Bone Miner Res 12(6):915–921

    Article  CAS  PubMed  Google Scholar 

  10. Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004) Genetics and biology of vitamin D receptor polymorphisms. Gene 338(2):143–156

    Article  CAS  PubMed  Google Scholar 

  11. Yasovanthi J, Venkata Karunakar K, Sri Manjari K, Pulla Reddy B, Ajeya Kumar P, Sesha Charyulu M et al (2011) Association of vitamin D receptor gene polymorphisms with BMD and their effect on 1, 25-dihydroxy vitamin D3 levels in pre- and postmenopausal South Indian women from Andhra Pradesh. Clin Chim Acta 412(7–8):541–544

    Article  CAS  PubMed  Google Scholar 

  12. Petersen MS, Bech S, Christiansen DH, Schmedes AV, Halling J (2014) The role of vitamin D levels and vitamin D receptor polymorphism on Parkinson’s disease in the Faroe Islands. Neurosci Lett 561:74–79

    Article  CAS  PubMed  Google Scholar 

  13. Torok R, Torok N, Szalardy L, Plangar I, Szolnoki Z, Somogyvari F et al (2013) Association of vitamin D receptor gene polymorphisms and Parkinson’s disease in Hungarians. Neurosci Lett 551:70–74

    Article  CAS  PubMed  Google Scholar 

  14. Liu HX, Han X, Zheng XP, Li YS, Xie AM (2013) Association of vitamin D receptor gene polymorphisms with Parkinson disease. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30(1):13–16

    PubMed  Google Scholar 

  15. Lv Z, Tang B, Sun Q, Yan X, Guo J (2013) Association study between vitamin d receptor gene polymorphisms and patients with Parkinson disease in Chinese Han population. Int J Neurosci 123(1):60–64

    Article  CAS  PubMed  Google Scholar 

  16. Han X, Xue L, Li Y, Chen B, Xie A (2012) Vitamin D receptor gene polymorphism and its association with Parkinson’s disease in Chinese Han population. Neurosci Lett 525(1):29–33

    Article  CAS  PubMed  Google Scholar 

  17. Kim JS, Kim YI, Song C, Yoon I, Park JW, Choi YB et al (2005) Association of vitamin D receptor gene polymorphism and Parkinson’s disease in Koreans. J Korean Med Sci 20(3):495–498

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Gezen-Ak D, Dursun E, Bilgic B, Hanagasi H, Ertan T, Gurvit H et al (2012) Vitamin D receptor gene haplotype is associated with late-onset Alzheimer’s disease. Tohoku J Exp Med 228(3):189–196

    Article  CAS  PubMed  Google Scholar 

  19. Lehmann DJ, Refsum H, Warden DR, Medway C, Wilcock GK, Smith AD (2011) The vitamin D receptor gene is associated with Alzheimer’s disease. Neurosci Lett 504(2):79–82

    Article  CAS  PubMed  Google Scholar 

  20. Gezen-Ak D, Dursun E, Ertan T, Hanagasi H, Gurvit H, Emre M et al (2007) Association between vitamin D receptor gene polymorphism and Alzheimer’s disease. Tohoku J Exp Med 212(3):275–282

    Article  CAS  PubMed  Google Scholar 

  21. Wang L, Hara K, Van Baaren JM, Price JC, Beecham GW, Gallins PJ et al (2012) Vitamin D receptor and Alzheimer’s disease: a genetic and functional study. Neurobiol Aging 33(8):e1–e9

    Article  Google Scholar 

  22. Luedecking-Zimmer E, DeKosky ST, Nebes R, Kamboh MI (2003) Association of the 3′ UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer’s disease. Am J Med Genet B Neuropsychiatr Genet 117B(1):114–117

    Article  PubMed  Google Scholar 

  23. Lin CH, Chen KH, Chen ML, Lin HI, Wu RM (2014) Vitamin D receptor genetic variants and Parkinson’s disease in a Taiwanese population. Neurobiol Aging 35(5):1212 e11–1212 e13

    Article  Google Scholar 

  24. Lee YH, Rho YH, Choi SJ, Ji JD, Song GG (2007) PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis. Rheumatol Int 27(9):827–833

    Article  CAS  PubMed  Google Scholar 

  25. Lee YH, Bae SC, Choi SJ, Ji JD, Song GG (2011) Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. Mol Biol Rep 38(6):3643–3651

    Article  CAS  PubMed  Google Scholar 

  26. Lee YH, Harley JB, Nath SK (2006) Meta-analysis of TNF-alpha promoter −308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet 14(3):364–371

    Article  CAS  PubMed  Google Scholar 

  27. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558

    Article  PubMed  Google Scholar 

  28. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188

    Article  CAS  PubMed  Google Scholar 

  29. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629–634

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29(1):21–30

    Article  CAS  PubMed  Google Scholar 

  31. Gross C, Krishnan AV, Malloy PJ, Eccleshall TR, Zhao XY, Feldman D (1998) The vitamin D receptor gene start codon polymorphism: a functional analysis of FokI variants. J Bone Miner Res 13(11):1691–1699

    Article  CAS  PubMed  Google Scholar 

  32. Morrison NA, Qi JC, Tokita A, Kelly PJ, Crofts L, Nguyen TV et al (1994) Prediction of bone density from vitamin D receptor alleles. Nature 367(6460):284–287

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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The authors have no financial or non-financial conflict of interest to declare.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University Anam Hospital, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea

    Young Ho Lee, Jae-Hoon Kim & Gwan Gyu Song

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  1. Young Ho Lee
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  2. Jae-Hoon Kim
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Correspondence to Young Ho Lee.

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Lee, Y.H., Kim, JH. & Song, G.G. Vitamin D receptor polymorphisms and susceptibility to Parkinson’s disease and Alzheimer’s disease: a meta-analysis. Neurol Sci 35, 1947–1953 (2014). https://doi.org/10.1007/s10072-014-1868-4

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  • DOI: https://doi.org/10.1007/s10072-014-1868-4

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