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Fibroblast growth factor 20 (FGF20) gene polymorphism and risk of Parkinson’s disease: a meta-analysis

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Abstract

Fibroblast growth factor 20 (FGF20) widely expressed in the substantia nigra is a neurotrophic factor and enhances the survival of midbrain dopaminergic neurons. Genetic association between variants in FGF20 gene (rs1721100) and PD has been reported, however, the results have been conflicting. A total of 3,463 PD patients and 4,606 controls from 5 case–control studies, which were identified by searching Web of Science, Embase and PubMed database up to March 2014, were collected for this meta-analysis. The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson’s disease under a recessive model (GG versus CG+GG; OR = 1.15, 95 % CI 1.02–1.29, p = 0.02) but not under a dominant model (CG+GG versus CC; OR = 1.03, 95 % CI 0.93–1.13, p = 0.57). These findings suggest that rs1721100 GG genotype within FGF20 gene is a risk factor for PD. To our knowledge, this is the first meta-analysis to access to the association of FGF20 gene rs1721100 polymorphism with PD risk.

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References

  1. de Lau LML, Breteler MMB (2006) Epidemiology of Parkinson’s disease. Lancet Neurol 5:525–535

    Article  PubMed  Google Scholar 

  2. Mizuno Y, Hattori N, Kubo S et al (2008) Progress in the pathogenesis and genetics of Parkinson’s disease. Philos Trans R Soc Lond B Biol Sci 363:2215–2227

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Jeffers M, Shimkets R, Prayaga S et al (2001) Identification of a novel human fibroblast fibroblast growth factor and characterization of its role in oncogenesis. Cancer Res 61:3131–3138

    CAS  PubMed  Google Scholar 

  4. Ohmachi S, Watanabe Y, Mikami T et al (2000) FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain. Biochem Biophys Res Commun 277:355–436

    Article  CAS  PubMed  Google Scholar 

  5. Ohmachi S, Mikami T, Konishi M et al (2003) Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c. J Neurosci Res 72:436–443

    Article  CAS  PubMed  Google Scholar 

  6. Rideout HJ, Dietrich P, Savalle M et al (2003) Regulation of a-synuclein by bFGF in cultured ventralmidbrain dopaminergic neurons. J Neurochem 84:803–813

    Article  CAS  PubMed  Google Scholar 

  7. Kirikoshi H, Sagara N, Saitoh T et al (2000) Molecular cloning and characterization of human FGF-20 on chromosome 8 p21.3-p22. Biochem Biophys Res Commun 274:337–343

    Article  CAS  PubMed  Google Scholar 

  8. Wang G, van der Walt JM, Mayhew G et al (2008) Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alphasynuclein. Am J Hum Genet 82:283–289

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Van der Walt JM, Noureddine MA, Kittappa R et al (2004) Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease. Am J Hum Genet 74:1121–1127

    Article  PubMed Central  PubMed  Google Scholar 

  10. Gao X, Scott WK, Wang G et al (2008) Gene-gene interaction between FGF20 and MAOB in Parkinson disease. Ann Hum Genet 72(Pt 2):157–162

    Article  CAS  PubMed  Google Scholar 

  11. Scott WK, Nance MA, Watts RL et al (2001) Complete genomic screen in Parkinson disease: evidence for multiple genes. JAMA 286(18):2239–2244

    Article  CAS  PubMed  Google Scholar 

  12. Clarimon J, Xiromerisiou G, Eerola J et al (2005) Lack of evidence for a genetic association between FGF20 and Parkinson’s disease in Finnish and Greek patients. BMC Neurol 5:11

    Article  PubMed Central  PubMed  Google Scholar 

  13. Wider C, Dachsel JC, Soto AI et al (2009) FGF20 and Parkinson’s disease: no evidence of association or pathogenicity via alpha-synuclein expression. Mov Disord 24:455–459

    Article  PubMed Central  PubMed  Google Scholar 

  14. Xu X, Wang N, Xu H et al (2013) Fibroblast growth factor 20 polymorphism in sporadic Parkinson’s disease in Northern Han Chinese. J Clin Neurosci 20(11):1588–1590

    Article  CAS  PubMed  Google Scholar 

  15. Satake W, Mizuta I, Suzuki S et al (2007) Fibroblast growth factor 20 gene and Parkinson’s disease in the Japanese population. NeuroReport 18:937–940

    Article  CAS  PubMed  Google Scholar 

  16. Pan J, Li H, Wang Y, Ma JF et al (2012) Fibroblast growth factor 20 (FGF20) polymorphism is a risk factor for Parkinson’s disease in Chinese population. Parkinsonism Relat Disord 18(5):629–631

    Article  PubMed  Google Scholar 

  17. de Mena L, Cardo LF, Coto E et al (2010) FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson’s disease in Spanish patients. Neurosci Lett 479:22–25

    Article  PubMed  Google Scholar 

  18. Ustinova VV, Shadrina MI, Fedotova EIu et al (2012) Analysis of the rs12720208 single-nucleotide polymorphism of the FGF20 gene in Russian patients with sporadic Parkinson’s disease. Genetika 48(12):1437–1439

    CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (30971018). We are deeply grateful to all participants of this study.

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Shenyang, 110001, China

    Ruixia Zhu, Ying Zhu, Xu Liu & Zhiyi He

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  1. Ruixia Zhu
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  2. Ying Zhu
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  3. Xu Liu
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  4. Zhiyi He
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Correspondence to Zhiyi He.

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Zhu, R., Zhu, Y., Liu, X. et al. Fibroblast growth factor 20 (FGF20) gene polymorphism and risk of Parkinson’s disease: a meta-analysis. Neurol Sci 35, 1889–1894 (2014). https://doi.org/10.1007/s10072-014-1853-y

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  • DOI: https://doi.org/10.1007/s10072-014-1853-y

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