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Serum phosphate concentration and incidence of stroke: a systemic review and meta-analysis

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Abstract

Elevated serum phosphate is associated with cardiovascular and total mortality in patients with kidney diseases and healthy individuals. But whether serum phosphate is associated with stroke is controversial. We searched PubMed and Embase from January 1, 1970 to May 9, 2014 with keywords such as “serum phosphate”, “serum phosphorus”, and “stroke”. Dose–response meta-analysis was conducted. A restricted cubic spline model was used, and then we estimated pooled RR using generalized least square regression taking into account the correlation among categories of each study. Five studies with a total of 32,608 patients were included. We identified a linear relationship between serum phosphate and risk of stroke (P for non-linearity = 0.5258). The RR of phosphate (1 mg/dL) for stroke was 1.00 (95 % CI 0.97–1.05), similar results were observed in subgroup analysis. A linear relationship between serum phosphate and risk of stroke is identified. There is no association between serum level of phosphate and stroke.

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References

  1. Palmer SC, Hayen A, Macaskill P, Pellegrini F, Craig JC, Elder GJ, Strippoli GF (2011) Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis. JAMA, J Am Med Assoc 305(11):1119–1127. doi:10.1001/jama.2011.308

    Article  CAS  Google Scholar 

  2. Wannamethee SG, Sattar N, Papcosta O, Lennon L, Whincup PH (2013) Alkaline phosphatase, serum phosphate, and incident cardiovascular disease and total mortality in older men. Arterioscler Thromb Vasc Biol 33(5):1070–1076

    Article  CAS  PubMed  Google Scholar 

  3. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T, O’Donnell M, Venketasubramanian N, Barker-Collo S, Lawes CM, Wang W, Shinohara Y, Witt E, Ezzati M, Naghavi M, Murray C (2014) Global and regional burden of stroke during 1990–2010: findings from the global burden of disease study 2010. Lancet 383(9913):245–254

    Article  PubMed Central  PubMed  Google Scholar 

  4. Luna JM, Moon YP, Liu KM, Spitalnik S, Paik MC, Cheung K, Sacco RL, Elkind MS (2014) High-sensitivity C-reactive protein and interleukin-6-dominant inflammation and ischemic stroke risk: the northern manhattan study. Stroke. doi:10.1161/STROKEAHA.113.002289

    Google Scholar 

  5. Cojocaru IM, Cojocaru M, Sapira V, Ionescu A, Barlan S, Tacu N (2013) Could pro-Bnp, uric acid, bilirubin, albumin and transferrin be used in making the distinction between stroke subtypes? J Neurol Sci 333:e174–e174

    Article  Google Scholar 

  6. Aronson D, Kapeliovich M, Hammerman H, Dragu R (2013) The relation between serum phosphorus levels and clinical outcomes after acute myocardial infarction. PLoS One 8(3):e58348

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Foley RN, Collins AJ, Ishani A, Kalra PA (2008) Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the atherosclerosis risk in communities (ARIC) study. Am Heart J 156(3):556–563

    Article  CAS  PubMed  Google Scholar 

  8. Slinin Y, Blackwell T, Ishani A, Cummings SR, Ensrud KE, Investigators M (2011) Serum calcium, phosphorus and cardiovascular events in post-menopausal women. Int J Cardiol 149(3):335–340. doi:10.1016/j.ijcard.2010.02.013

    Article  PubMed  Google Scholar 

  9. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G (2005) Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 112(17):2627–2633

    Article  CAS  PubMed  Google Scholar 

  10. Lo CK, Mertz D, Loeb M (2014) Newcastle-Ottawa Scale: comparing reviewers′ to authors′ assessments. BMC Med Res Methodol 14:45

  11. Yousaf F, Charytan C (2014) Review of cinacalcet hydrochloride in the management of secondary hyperparathyroidism. Ren Fail 36(1):131–138

    Article  CAS  PubMed  Google Scholar 

  12. Orsini N, Bellocco R, Greenland S (2006) Generalized least squares for trend estimation of summarized dose–response data. Stata Journal 6(1):40

    Google Scholar 

  13. Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM (2011) Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res 109(6):697–711. doi:10.1161/CIRCRESAHA.110.234914

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

We thank Professor Chengbin Xu (Library of the third military university, Chongqing, China) for his kindly help in making search strategy.

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Authors and Affiliations

  1. Institute of Cardiovascular Surgery, Xinqiao Hospital, Third Military Medical University, No. 183 Xinqiao Street, 400037, Chongqing, People’s Republic of China

    Jing-Wei Li & Ying-Bin Xiao

  2. Medical Department, 305 Hospital of PLA, 100034, Beijing, People’s Republic of China

    Cui Xu

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  1. Jing-Wei Li
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  2. Cui Xu
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Correspondence to Ying-Bin Xiao.

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Li, JW., Xu, C. & Xiao, YB. Serum phosphate concentration and incidence of stroke: a systemic review and meta-analysis. Neurol Sci 35, 1877–1882 (2014). https://doi.org/10.1007/s10072-014-1850-1

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  • DOI: https://doi.org/10.1007/s10072-014-1850-1

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