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The polymorphism of ARNTL2 (BMAL2) gene rs2306074 C>T is associated with susceptibility of Alzheimer disease in Chinese population

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Abstract

In the present study, we investigated whether polymorphism of ARNTL2 (BMAL2) gene rs2306074 T/C was associated with susceptibility of Alzheimer disease (AD) in Chinese population. A case–control method was employed in this study. 296 unrelated AD patients and 423 control subjects were recruited in current study. The prevalence of C carriers in BMAL2 gene rs2306074 T/C in AD patients was significantly higher than that of control subjects in both the whole sample and APOE ε 4 non-carriers (in the whole sample: χ 2 = 5.938, P = 0.012; in APOE ε 4 non-carriers: χ 2 = 9.048, P < 0.0001). In addition, both in the whole sample and APOE ε 4 non-carriers, prevalence of CC genotypes in BMAL2 gene rs2306074 of AD patients was also significantly higher than that in controls (in the whole sample: χ 2 = 5.126, P = 0.018; in APOE ε 4 non-carriers: χ 2 = 7.389, P = 0.023). However, there was no significant difference of prevalence of C carriers and CC genotypes in BMAL2 gene rs2306074 T/C between AD patients and control subjects among APOE ε 4 carriers (C carriers: χ 2 = 0.020, P = 0.900; CC genotypes: χ 2 = 0.017, P = 0.946). C carriers in BMAL2 gene rs2306074 T/C are associated with a high susceptibility of AD among APOE ε 4 non-carriers but not among APOE ε 4 carriers in Chinese population.

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Acknowledgments

This work was supported by the Science and Technology Graveness Project of Sichuan Province (2010FZ0061) and from the Illustrious Youth Specialist Project of Sichuan Province (2012JQ005). The authors thank the staff of the Key Laboratory of Chronobiology of Health Ministry in Basic and Forensic School of Sichuan University, and the Department of Geriatrics of the third hospital of Mianyang, and all study participants (as well as their legal proxies) for their great contributions.

Conflict of interest

The authors wish to extend their full confidence that there are no conflicts of interest in this research article and that only the fullest integrity was practiced in its composition.

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Authors and Affiliations

  1. Department of Geriatrics, The Third Hospital of Mianyang, Jiannanlu 190, Mianyang, 621000, Sichuang Province, China

    Liu Qing-Xiu & Huang Chang-Quan

  2. Department of Geriatrics, The West-hospital of Sichuan University, Chengdu, China

    Chen Qian, Zhang Xue-Mei, Hu Xiu-Ying & Li Song-Bing

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  1. Liu Qing-Xiu
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  2. Huang Chang-Quan
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  3. Chen Qian
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  4. Zhang Xue-Mei
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  5. Hu Xiu-Ying
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  6. Li Song-Bing
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Correspondence to Huang Chang-Quan.

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Qing-Xiu, L., Chang-Quan, H., Qian, C. et al. The polymorphism of ARNTL2 (BMAL2) gene rs2306074 C>T is associated with susceptibility of Alzheimer disease in Chinese population. Neurol Sci 35, 1743–1747 (2014). https://doi.org/10.1007/s10072-014-1824-3

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  • DOI: https://doi.org/10.1007/s10072-014-1824-3

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