Neurological Sciences

, Volume 35, Issue 11, pp 1723–1730 | Cite as

Vitamin D status and Parkinson’s disease: a systematic review and meta-analysis

  • Zheng Lv
  • Huiping Qi
  • Le Wang
  • Xiaoxue Fan
  • Fei Han
  • Hong Wang
  • Sheng BiEmail author
Original Article


To estimate the associations between vitamin D status and Parkinson’s disease (PD). We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to February, 2014 using the following keywords: ‘vitamin D’ or ‘25(OH)D’ and ‘status’ or ‘deficiency’ or ‘insufficiency’ and ‘Parkinson’s disease’. A systematic review and meta-analysis were conducted on observational studies that reported the association between blood vitamin D levels and PD. Seven studies met the inclusion criteria. 1,008 patients and 4,536 controls were included. Results of our meta-analysis show that PD patients had lower mean levels of 25-hydroxyvitamin D [25(OH)D] than healthy controls [weighted mean difference (MD), −16.9, 95 % confidence interval (CI)], −33.5 to −0.2). Patients with vitamin D insufficiency [25(OH)D level <75 nmol/l] had an increased risk of PD (OR 1.5, 95 % CI 1.1–2.0). Patients with vitamin D deficiency [25(OH)D level <50 nmol/l] experienced a twofold increased risk of PD (OR 2.2, 95 % CI 1.5–3.4). Low vitamin D levels are associated with an increased risk of PD.


Parkinson’s disease Vitamin D 25-Hydroxy vitamin D Deficiency Systematic review Meta-analysis 



This work was supported by the Harbin Special Funds for Research of Scientific and Technological Innovative Talents (No. 2011RFQYS092) and Innovative Foundation of the Harbin Medical University (HCXS2010014).

Conflict of interest

The authors report no conflict of interest.


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Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  • Zheng Lv
    • 1
  • Huiping Qi
    • 2
  • Le Wang
    • 3
  • Xiaoxue Fan
    • 3
  • Fei Han
    • 3
  • Hong Wang
    • 3
  • Sheng Bi
    • 3
    Email author
  1. 1.Department of Rehabilitation, the First Affiliated HospitalHarbin Medical UniversityHarbinChina
  2. 2.Department of Neurology, the Fourth Affiliated HospitalHarbin Medical UniversityHarbinChina
  3. 3.Department of Neurology, the First Affiliated HospitalHarbin Medical UniversityHarbinChina

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