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From the liver to the brain: manganese matters

Focus on cirrhosis-related Parkinsonism

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References

  1. Maffeo E, Montuschi A, Stura G, Giordana MT (2013) Chronic acquired hepatocerebral degeneration, pallidal T1 MRI hyperintensity and manganese in a series of cirrhotic patients. Neurol Sci (Epub ahead of print)

  2. Victor M, Adams RD, Cole M (1965) The acquired (non-Wilsonian) type of chronic hepatocerebral degeneration. Medicine (Baltimore) 44(5):345–396

    Article  CAS  Google Scholar 

  3. Krieger D, Krieger S, Jansen O, Gass P, Theilmann L, Lichtnecker H (1995) Manganese and chronic hepatic encephalopathy. Lancet 346(8970):270–274

    Article  CAS  PubMed  Google Scholar 

  4. Burkhard PR, Delavelle J, Du Pasquier R, Spahr L (2003) Chronic parkinsonism associated with cirrhosis: a distinct subset of acquired hepatocerebral degeneration. Arch Neurol 60(4):521–528

    Article  PubMed  Google Scholar 

  5. Tryc AB, Goldbecker A, Berding G, Rümke S, Afshar K, Shahrezaei GH, Pflugrad H, Barg-Hock H, Strassburg CP, Hecker H, Weissenborn K (2013) Cirrhosis-related Parkinsonism: prevalence, mechanisms and response to treatments. J Hepatol 58(4):698–705

    Article  CAS  PubMed  Google Scholar 

  6. Butterworth RF (2013) Parkinsonism in cirrhosis: pathogenesis and current therapeutic options. Metab Brain Dis 28(2):261–267

    CAS  PubMed  Google Scholar 

  7. Quadri M, Federico A, Zhao T, Breedveld GJ, Battisti C, Delnooz C, Severijnen LA, Di Toro Mammarella L, Mignarri A, Monti L, Sanna A, Lu P, Punzo F, Cossu G, Willemsen R, Rasi F, Oostra BA, van de Warrenburg BP, Bonifati V (2012) Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease. Am J Hum Genet 90(3):467–477

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Di Toro Mammarella L, Mignarri A, Battisti C, Monti L, Bonifati V, Rasi F, Federico A (2014) Two-year follow-up after chelating therapy in a patient with adult-onset parkinsonism and hypermanganesaemia due to SLC30A10 mutations. J Neurol 261(1):227–228

    Article  Google Scholar 

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Authors and Affiliations

  1. Unit of Neurology and Neurometabolic Disorders, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy

    Andrea Mignarri & Antonio Federico

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  1. Andrea Mignarri
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  2. Antonio Federico
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Correspondence to Andrea Mignarri.

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Mignarri, A., Federico, A. From the liver to the brain: manganese matters. Neurol Sci 35, 521–522 (2014). https://doi.org/10.1007/s10072-014-1665-0

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