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Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis

Neurological Sciences volume 35, pages 789–791 (2014)Cite this article

Abstract

Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands’ clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.

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Acknowledgments

The project was sponsored by the Grant Giovani Ricercatori 2007 (D.lgs 502/92) from the Italian Ministry of Health, FISM (Projects: 2008/R/15 and Progetto Speciale Immunochip), Cariplo Foundation (Grant 2010.0728), and CRT Foundation of Turin Italy.

Conflict of interest

The authors declare the following conflicts of interest: Dr. Martinelli Boneschi has received speaker honoraria and funding for travel from Sanofi-Aventis, Biogen-Dompè. He receives research support from the Grant Giovani Ricercatori 2007 (D.lgs 502/92) from the Italian Ministry of Health, Fondazione Cariplo, and Fondazione Italiana Sclerosi Multipla. Prof. Comi has in the past year received honorarium for speaking and consulting activities from Bayer Schering, Serono Symposia International Foundation, Merck Serono International, Sanofi-Aventis, Biogen-Dompè, Teva Pharmaceutical Ind. Ltd., Novartis. Prof. Tedeschi in the past years received honorarium for speaking and consulting activities from Bayer Schering, Serono Symposia International Foundation, Merck Serono International, Sanofi-Aventis, Biogen-Dompè, Teva Pharmaceutical Ind. Ltd., Novartis. Dr. Martinelli received speaker honoraria or fundings for travels from Biogen-Dompè. SG, Merck Serono, Bayer Schering Pharma, Novartis and Sanofi-Aventis. Dr. Capello has received speaker honoraria from Novartis and Biogen-Dompè. P. Annovazzi has served as consultant to Biogen-Idec and Teva Pharmaceuticals and received speakers’ bureaus for Biogen-Idec and Teva Pharmaceuticals. Dr. F. Esposito received honorarium for consulting activities from Serono Symposia International Foundation. Dr. Guaschino, Dr. Liberatore report no disclosures. The other co-authors report no disclosures.

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Affiliations

  1. Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of Neuroscience, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy

    Clara Guaschino, Federica Esposito, Giuseppe Liberatore, Bruno Colombo, Vittorio Martinelli, Giancarlo Comi & Filippo Martinelli-Boneschi

  2. Department of Neurology, S. Antonio Abate Hospital, Gallarate, Italy

    Pietro Annovazzi

  3. Department of Neurological Sciences, University of Catania, Catania, Italy

    Emanuele D’Amico

  4. Department of Neurology, University of Turin, Turin, Italy

    Paola Cavalla

  5. Department of Neuroscience Ophthalmology and Genetics, University of Genoa, Genoa, Italy

    Elisabetta Capello

  6. Multiple Sclerosis Centre, Spedali Civili, Brescia, Italy

    Ruggero Capra

  7. Department of Neurological Sciences, Centro Dino Ferrari, Fondazione Ca` Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy

    Daniela Galimberti

  8. Department of Neurological Sciences, Second University of Naples, Naples, Italy

    Gioacchino Tedeschi

  9. Division of Neurology, Fondazione Istituto San Raffaele “G. Giglio”, Cefalù, Italy

    Luigi Grimaldi

  10. MS Centre, SCDU Neurology AOU Maggiore della Carità, Novara, Italy

    Maurizio Leone & Sandra D’Alfonso

  11. Department of Health Sciences, University of Eastern Piedmont, Novara, Italy

    Sandra D’Alfonso

Authors
  1. Clara Guaschino
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  2. Federica Esposito
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  3. Giuseppe Liberatore
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  4. Bruno Colombo
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  5. Pietro Annovazzi
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  6. Emanuele D’Amico
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  7. Paola Cavalla
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  8. Elisabetta Capello
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  9. Ruggero Capra
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  10. Daniela Galimberti
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  11. Gioacchino Tedeschi
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  12. Luigi Grimaldi
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  13. Maurizio Leone
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  14. Sandra D’Alfonso
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  15. Vittorio Martinelli
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  16. Giancarlo Comi
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  17. Filippo Martinelli-Boneschi
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Consortia

PROGRESSO Group

PROGEMUS Group

Corresponding author

Correspondence to Filippo Martinelli-Boneschi.

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Guaschino, C., Esposito, F., Liberatore, G. et al. Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis. Neurol Sci 35, 789–791 (2014). https://doi.org/10.1007/s10072-014-1650-7

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  • DOI: https://doi.org/10.1007/s10072-014-1650-7

Keywords

  • Multiple sclerosis
  • Progressive
  • Relapsing–remitting
  • Recurrence risk